Protein: ERG6
Sterol 24-C-methyltransferase ERG6 (SCMT) (EC 2.1.1.41) (Delta(24)-sterol C-methyltransferase ERG6) (Ergosterol biosynthetic protein 6)

Gene: ERG6
Organism: Saccharomyces cerevisiae S288C
Interactions: 112
UniProt ID: P25087

Gene Ontology (top 5):
GO:0003838 - sterol 24-C-methyltransferase activity
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005783 - endoplasmic reticulum
GO:0005811 - lipid droplet

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

668877

ERG6
Sterol 24-C-methyltransferase ERG6

4

9

Small-scale

0.887

High

668917

ERG28
Ergosterol biosynthetic protein 28

3

0

Small-scale

0.653

High

577364

MTF1
Mitochondrial transcription factor 1

1

0

High-throughput

0.631

High

668926

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

3

High-throughput

0.584

High

668972

OSH2
Oxysterol-binding protein homolog 2

1

2

Small-scale

0.573

High

525988

HSP72
Heat shock protein SSA2

2

5

High-throughput

0.571

High

523141

HSP71
Heat shock protein SSA1

3

5

High-throughput

0.569

High

528550

CP51
Lanosterol 14-alpha demethylase CYP51

1

1

Small-scale

0.541

High

668879

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

1

Small-scale

0.541

High

668887

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

1

Small-scale

0.541

High

668888

ERG24
Delta(14)-sterol reductase ERG24

1

1

Small-scale

0.541

High

668935

ERG25
C-4 methylsterol oxidase ERG25

1

1

Small-scale

0.541

High

668945

ERG5
C-22 sterol desaturase ERG5

1

1

Small-scale

0.541

High

668954

SEN15
tRNA-splicing endonuclease subunit SEN15

1

1

High-throughput

0.536

High

543908

SSB1
Ribosome-associated molecular chaperone SSB1

2

6

High-throughput

0.521

High

668884

ERG9
Squalene synthase ERG9

1

0

Small-scale

0.518

High

668886

ERG2
C-8 sterol isomerase ERG2

1

0

Small-scale

0.518

High

668906

ERG7
Lanosterol synthase ERG7

1

0

Small-scale

0.518

High

668915

SEC72
Translocation protein SEC72

1

0

High-throughput

0.518

High

668927

SPC1
Signal peptidase complex subunit 1

1

0

High-throughput

0.518

High

668938

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

0

Small-scale

0.518

High

668973

ERG27
3-keto-steroid reductase ERG27

1

0

Small-scale

0.518

High

668953

MYO5
Myosin-5

1

2

Small-scale

0.504

High

668918

IMB4
Importin subunit beta-4

1

1

Small-scale

0.489

High

668882

MSP1
Outer mitochondrial transmembrane helix translocase

1

3

High-throughput

0.481

High

668885

OAC1
Mitochondrial oxaloacetate transport protein

1

2

High-throughput

0.481

High

668890

TOR2
Serine/threonine-protein kinase TOR2

1

3

High-throughput

0.481

High

668899

MCR1
NADH-cytochrome b5 reductase 2

1

2

High-throughput

0.481

High

668907

NCB5R
NADH-cytochrome b5 reductase 1

1

2

High-throughput

0.481

High

668908

TCD1
tRNA threonylcarbamoyladenosine dehydratase 1

1

2

High-throughput

0.481

High

668910

TOM71
Protein TOM71

1

3

High-throughput

0.481

High

668911

KOG1
Target of rapamycin complex 1 subunit KOG1

1

3

High-throughput

0.481

High

668913

PET8
Putative mitochondrial carrier protein PET8

1

1

High-throughput

0.481

High

668920

AYR1
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase

1

1

High-throughput

0.481

High

668923

DJP1
DnaJ-like protein 1

1

6

High-throughput

0.481

High

668929

MDV1
Mitochondrial division protein 1

1

3

High-throughput

0.481

High

668939

PEX31
Peroxisomal membrane protein PEX31

1

1

High-throughput

0.481

High

668942

DSL1
Protein transport protein DSL1

1

1

High-throughput

0.481

High

668960

DIC1
Mitochondrial dicarboxylate transporter

1

2

High-throughput

0.481

High

668961

PEX30
Peroxisomal membrane protein PEX30

1

1

High-throughput

0.481

High

578899

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.479

High

668881

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

668900

LONM
Lon protease homolog, mitochondrial

1

3

High-throughput

0.479

High

668909

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.479

High

668956

RTN1
Reticulon-like protein 1

1

1

Small-scale

0.479

High

668958

BSC2
Bypass of stop codon protein 2

1

1

Small-scale

0.479

High

668974

SMC6
Structural maintenance of chromosomes protein 6

1

5

High-throughput

0.479

High

519021

COX7
Cytochrome c oxidase subunit 7, mitochondrial

1

0

High-throughput

0.460

High

569378

DPM1
Dolichol-phosphate mannosyltransferase

1

0

High-throughput

0.460

High

647264

QCR9
Cytochrome b-c1 complex subunit 9, mitochondrial

1

0

High-throughput

0.460

High

668892

SC61A
Protein transport protein SEC61

1

0

Small-scale

0.460

High

668894

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

0

Small-scale

0.460

High

668895

PTH2
Peptidyl-tRNA hydrolase 2

1

0

High-throughput

0.460

High

668901

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.460

High

668905

OM14
Mitochondrial outer membrane protein OM14

1

0

High-throughput

0.460

High

668916

FMP52
Protein FMP52, mitochondrial

1

0

High-throughput

0.460

High

668921

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.460

High

668924

MMM1
Maintenance of mitochondrial morphology protein 1

1

0

High-throughput

0.460

High

668930

IML2
Inclusion body clearance protein IML2

1

0

High-throughput

0.460

High

668931

TIM54
Mitochondrial import inner membrane translocase subunit TIM54

1

0

High-throughput

0.460

High

668934

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.460

High

668936

MDM34
Mitochondrial distribution and morphology protein 34

1

0

High-throughput

0.460

High

668937

GET1
Golgi to ER traffic protein 1

1

0

High-throughput

0.460

High

668943

FOL1
Folic acid synthesis protein FOL1 [Includes: Dihydroneopterin aldolase

1

0

High-throughput

0.460

High

668944

RHO5
GTP-binding protein RHO5

1

0

Small-scale

0.460

High

668948

PEX29
Peroxisomal membrane protein PEX29

1

0

High-throughput

0.460

High

668955

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.460

High

668962

LEC1
PX domain-containing protein LEC1

1

0

Small-scale

0.460

High

668963

PEX19
Peroxisomal membrane protein import receptor PEX19

1

0

High-throughput

0.460

High

647014

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

668880

LDB16
Protein LDB16

1

0

Small-scale

0.458

High

668925

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

668950

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

668959

SEI1
Seipin

1

0

Small-scale

0.458

High

668964

LAM6
Membrane-anchored lipid-binding protein LAM6

1

0

Small-scale

0.458

High

668969

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.458

High

668896

PEX5
Peroxisomal targeting signal receptor

1

1

High-throughput

0.439

High

668897

TOR1
Serine/threonine-protein kinase TOR1

1

3

High-throughput

0.439

High

668932

JSN1
Protein JSN1

1

3

High-throughput

0.439

High

392278

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.437

High

645682

HSP74
Heat shock protein SSA4

1

5

High-throughput

0.437

High

668878

SIS1
Protein SIS1

1

4

High-throughput

0.437

High

668883

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

668893

PRS6A
26S proteasome regulatory subunit 6A

1

3

High-throughput

0.437

High

668912

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.437

High

668951

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.437

High

668971

DBP10
ATP-dependent RNA helicase DBP10

1

7

High-throughput

0.437

High

590541

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

668889

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.407

High

668919

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.407

High

668898

DYHC
Dynein heavy chain, cytoplasmic

2

0

Small-scale

0.326

High

668967

NUR1
Nuclear rim protein 1

1

0

High-throughput

0.282

High

668970

YOR97
Uncharacterized protein YOR097C

1

0

High-throughput

0.282

High

668891

PEX2
Peroxisomal biogenesis factor 2

1

0

High-throughput

0.251

Low

668904

PEX32
Peroxisomal membrane protein PEX32

1

0

High-throughput

0.251

Low

668922

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

High-throughput

0.251

Low

668941

YTP1
Protein YTP1

1

0

High-throughput

0.251

Low

668946

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.251

Low

668947

PEX25
Peroxisomal membrane protein PEX25

1

0

High-throughput

0.251

Low

668949

INP1
Inheritance of peroxisomes protein 1

1

0

High-throughput

0.251

Low

668952

PEX12
Peroxisome assembly protein 12

1

0

High-throughput

0.251

Low

668957

PEX10
Peroxisome biogenesis factor 10

1

0

High-throughput

0.251

Low

668968

DAP1
Damage response protein 1

1

0

High-throughput

0.251

Low

668902

AP3M
AP-3 complex subunit mu

1

0

High-throughput

0.249

Low

668903

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

668914

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

668933

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

668940

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

668965

MCA1
Metacaspase-1

1

0

High-throughput

0.249

Low

668966

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

668928

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025