Protein: MID2
Cell wall integrity sensor MID2 (Mating pheromone-induced death protein 2) (Protein kinase A interference protein 1) (Serine-rich multicopy suppressor protein 1)

Gene: MID2
Organism: Saccharomyces cerevisiae S288C
Interactions: 94
UniProt ID: P36027

Gene Ontology (top 5):
GO:0000324 - fungal-type vacuole
GO:0000425 - pexophagy
GO:0004888 - transmembrane signaling receptor activity
GO:0005886 - plasma membrane
GO:0006970 - response to osmotic stress

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

678092

SYP1
Suppressor of yeast profilin deletion

3

6

Small-scale

0.668

High

779895

PST2
Protoplast secreted protein 2

2

0

Small-scale

0.609

High

779849

OSH7
Oxysterol-binding protein homolog 7

2

0

High-throughput

0.587

High

779887

ZEO1
Protein ZEO1

2

0

Small-scale

0.570

High

376222

RAS2
Ras-like protein 2

1

6

Small-scale

0.552

High

587299

ABP1
Actin-binding protein

1

4

Small-scale

0.552

High

656421

KC11
Casein kinase I homolog 1

1

1

Small-scale

0.552

High

779853

SSO2
Protein SSO2

1

3

Small-scale

0.552

High

720830

ITR1
Myo-inositol transporter 1

1

1

High-throughput

0.541

High

737214

HXT1
Low-affinity glucose transporter HXT1

1

1

High-throughput

0.541

High

779846

MID2
Cell wall integrity sensor MID2

1

7

High-throughput

0.541

High

779854

FTR1
Plasma membrane iron permease

1

1

High-throughput

0.541

High

779856

QDR2
Quinidine resistance protein 2

1

5

High-throughput

0.541

High

779868

VHT1
Vitamin H transporter

1

2

High-throughput

0.541

High

779869

TPO2
Polyamine transporter 2

1

6

High-throughput

0.541

High

779871

WSC2
Cell wall integrity and stress response component 2

1

8

High-throughput

0.541

High

779874

ATN2
Sodium/potassium exporting P-type ATPase 2

1

3

High-throughput

0.541

High

779882

MYO5
Myosin-5

1

4

High-throughput

0.541

High

779886

TPO1
Polyamine transporter 1

1

6

High-throughput

0.541

High

779891

WSC3
Cell wall integrity and stress response component 3

1

8

High-throughput

0.541

High

779893

TPO4
Polyamine transporter 4

1

6

High-throughput

0.541

High

533168

GPA2
Guanine nucleotide-binding protein alpha-2 subunit

1

0

High-throughput

0.518

High

625889

HNM1
Choline transporter

1

0

High-throughput

0.518

High

663312

FPS1
Glycerol uptake/efflux facilitator protein

1

0

High-throughput

0.518

High

678037

HSP30
30 kDa heat shock protein

1

0

High-throughput

0.518

High

740251

SMI1
Cell wall assembly regulator SMI1

1

0

High-throughput

0.518

High

776716

SFK1
Protein SFK1

1

0

High-throughput

0.518

High

779857

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

1

0

High-throughput

0.518

High

779863

MUP1
High-affinity methionine permease

1

0

High-throughput

0.518

High

779865

YOR1
Oligomycin resistance ATP-dependent permease YOR1

1

0

High-throughput

0.518

High

779870

MEP3
Ammonium transporter MEP3

1

0

High-throughput

0.518

High

779876

PDR12
ATP-dependent permease PDR12

1

0

High-throughput

0.518

High

779878

RSN1
Uncharacterized protein RSN1

1

0

High-throughput

0.518

High

779879

TCB3
Tricalbin-3

1

0

High-throughput

0.518

High

779880

EFR3
Protein EFR3

1

0

High-throughput

0.518

High

779885

FMP45
SUR7 family protein FMP45

1

0

High-throughput

0.518

High

779889

PIN2
[PSI+] induction protein 2

1

0

High-throughput

0.518

High

779892

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

0

High-throughput

0.518

High

779898

ATC4
Phospholipid-transporting ATPase DNF2

1

0

High-throughput

0.518

High

779864

ROM2
RHO1 GDP-GTP exchange protein 2

1

3

Small-scale

0.508

High

509888

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

1

2

Small-scale

0.504

High

779884

CORO
Coronin-like protein

1

3

Small-scale

0.504

High

687046

PPZ1
Serine/threonine-protein phosphatase PP-Z1

1

8

High-throughput

0.494

High

779852

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

3

High-throughput

0.494

High

779858

MAM33
Mitochondrial acidic protein MAM33

1

1

High-throughput

0.494

High

779861

BBC1
Myosin tail region-interacting protein MTI1

1

7

High-throughput

0.494

High

544441

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

Small-scale

0.481

High

623835

MYO2
Myosin-2

1

3

Small-scale

0.481

High

779855

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

Small-scale

0.481

High

779872

RHO5
GTP-binding protein RHO5

1

18

Small-scale

0.481

High

779873

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

1

High-throughput

0.481

High

779877

COFI
Cofilin

1

1

Small-scale

0.481

High

420912

PMA1
Plasma membrane ATPase 1

1

2

Small-scale

0.479

High

779859

GST1
Glutathione S-transferase 1

1

0

Small-scale

0.460

High

585545

BGL2
Glucan 1,3-beta-glucosidase

1

0

Small-scale

0.458

High

645240

GAS1
1,3-beta-glucanosyltransferase GAS1

1

0

Small-scale

0.458

High

779899

PGA3
Plasma membrane-associated coenzyme Q6 reductase PGA3

1

0

Small-scale

0.458

High

779847

FTH1
Iron transporter FTH1

1

1

High-throughput

0.457

High

436376

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

3

Small-scale

0.439

High

666168

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

2

Small-scale

0.439

High

779875

NACB1
Nascent polypeptide-associated complex subunit beta-1

1

1

Small-scale

0.439

High

571823

SNA3
Protein SNA3

1

0

High-throughput

0.438

High

585906

CSK21
Casein kinase II subunit alpha

1

5

High-throughput

0.417

High

622926

CSK22
Casein kinase II subunit alpha'

1

6

High-throughput

0.417

High

779896

RTN2
Reticulon-like protein 2

1

1

High-throughput

0.417

High

746126

PEP12
Syntaxin PEP12

1

3

Small-scale

0.407

High

528574

CP51
Lanosterol 14-alpha demethylase CYP51

1

0

High-throughput

0.282

High

636298

ACO1
Acyl-CoA desaturase 1

1

0

High-throughput

0.282

High

668452

SPTC1
Serine palmitoyltransferase 1

1

0

High-throughput

0.282

High

736548

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

1

0

High-throughput

0.282

High

779866

YGK8
Uncharacterized protein YGL108C

1

0

High-throughput

0.282

High

779867

SDS23
Protein SDS23

1

0

High-throughput

0.282

High

779883

DYN3
Cytoplasmic dynein intermediate light chain DYN3

1

0

High-throughput

0.282

High

779894

GIN4
Serine/threonine-protein kinase GIN4

1

0

High-throughput

0.282

High

779900

AP2M
AP-2 complex subunit mu

1

0

Small-scale

0.261

Low

394443

EF1A
Elongation factor 1-alpha

1

0

Small-scale

0.251

Low

409713

RL24A
Large ribosomal subunit protein eL24A

1

0

Small-scale

0.251

Low

439311

PDC1
Pyruvate decarboxylase isozyme 1

1

0

Small-scale

0.251

Low

450569

FAS1
Fatty acid synthase subunit beta

1

0

Small-scale

0.251

Low

506447

U5072
UPF0507 protein YML002W

1

0

Small-scale

0.251

Low

572557

ALF
Fructose-bisphosphate aldolase

1

0

Small-scale

0.251

Low

628060

FKBP
FK506-binding protein 1

1

0

Small-scale

0.251

Low

673352

GLRX1
Glutaredoxin-1

1

0

Small-scale

0.251

Low

779848

ATX1
Copper chaperone ATX1

1

0

Small-scale

0.251

Low

779850

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

Small-scale

0.251

Low

779851

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

Small-scale

0.251

Low

779860

RSSA2
Small ribosomal subunit protein uS2B

1

0

Small-scale

0.251

Low

779862

MTR3
Exosome complex component MTR3

1

0

Small-scale

0.251

Low

779881

MSH6
DNA mismatch repair protein MSH6

1

0

Small-scale

0.251

Low

779888

NBR9
Endonuclease NBR9

1

0

Small-scale

0.251

Low

779897

PAR32
Protein PAR32

1

0

Small-scale

0.251

Low

779890

NPC1
NPC intracellular sterol transporter 1-related protein 1

1

0

High-throughput

0.249

Low

609269

CPT1
Cholinephosphotransferase 1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025