Protein: SPT21
Protein SPT21

Gene: SPT21
Organism: Saccharomyces cerevisiae S288C
Interactions: 232
UniProt ID: P35209

Gene Ontology (top 5):
GO:0000183 - rDNA heterochromatin formation
GO:0000781 - chromosome, telomeric region
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0030466 - silent mating-type cassette heterochromatin formation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

640837

CDC20
APC/C activator protein CDC20

2

1

High-throughput

0.586

High

716221

SPT10
Protein SPT10

2

0

Small-scale

0.569

High

510848

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.536

High

355442

H2B1
Histone H2B.1

1

1

High-throughput

0.479

High

355859

H2B2
Histone H2B.2

1

1

High-throughput

0.479

High

577149

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

1

High-throughput

0.479

High

603300

SNF2
Transcription regulatory protein SNF2

1

3

High-throughput

0.479

High

635831

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

1

High-throughput

0.479

High

664753

BMH1
Protein BMH1

1

1

High-throughput

0.479

High

695938

HSP79
Heat shock protein homolog SSE2

1

3

High-throughput

0.479

High

696131

SWI3
SWI/SNF complex subunit SWI3

1

1

High-throughput

0.479

High

696195

STH1
Nuclear protein STH1/NPS1

1

3

High-throughput

0.479

High

697901

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

1

High-throughput

0.479

High

703151

UFD4
Ubiquitin fusion degradation protein 4

1

1

High-throughput

0.479

High

703777

PRS6B
26S proteasome regulatory subunit 6B homolog

1

1

High-throughput

0.479

High

712893

BMH2
Protein BMH2

1

1

High-throughput

0.479

High

715310

SPT7
Transcriptional activator SPT7

1

1

High-throughput

0.479

High

715668

TAF14
Transcription initiation factor TFIID subunit 14

1

1

High-throughput

0.479

High

716410

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

2

High-throughput

0.479

High

716438

PRS4
26S proteasome regulatory subunit 4 homolog

1

1

High-throughput

0.479

High

716452

RSC8
Chromatin structure-remodeling complex protein RSC8

1

1

High-throughput

0.479

High

716466

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

1

High-throughput

0.479

High

716474

CDH1
APC/C activator protein CDH1

1

1

High-throughput

0.479

High

716486

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.479

High

716497

SKY1
Serine/threonine-protein kinase SKY1

1

1

High-throughput

0.479

High

716521

NEW1
[NU+] prion formation protein 1

1

1

High-throughput

0.479

High

716532

H2AZ
Histone H2A.Z

1

1

High-throughput

0.479

High

356396

H4
Histone H4

1

0

High-throughput

0.458

High

381447

GAL1
Galactokinase

1

0

High-throughput

0.458

High

389638

DNLI1
DNA ligase 1

1

0

High-throughput

0.458

High

392387

H2A2
Histone H2A.2

1

0

High-throughput

0.458

High

423675

ADR1
Regulatory protein ADR1

1

0

High-throughput

0.458

High

424847

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.458

High

452094

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

0

High-throughput

0.458

High

454907

CDC16
Anaphase-promoting complex subunit CDC16

1

0

High-throughput

0.458

High

474132

HAP1
Heme-responsive zinc finger transcription factor HAP1

1

0

High-throughput

0.458

High

519508

PDR1
Transcription factor PDR1

1

0

High-throughput

0.458

High

520598

YPK1
Serine/threonine-protein kinase YPK1

1

0

High-throughput

0.458

High

526620

PCY1
Choline-phosphate cytidylyltransferase

1

0

High-throughput

0.458

High

530003

STE12
Protein STE12

1

0

High-throughput

0.458

High

539460

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

1

0

High-throughput

0.458

High

561230

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.458

High

581352

MED14
Mediator of RNA polymerase II transcription subunit 14

1

0

High-throughput

0.458

High

586288

MED15
Mediator of RNA polymerase II transcription subunit 15

1

0

High-throughput

0.458

High

597575

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.458

High

600925

UBC1
Ubiquitin-conjugating enzyme E2 1

1

0

High-throughput

0.458

High

604672

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.458

High

609075

SIN3
Transcriptional regulatory protein SIN3

1

0

High-throughput

0.458

High

611722

TRX2
Thioredoxin-2

1

0

High-throughput

0.458

High

622006

SSD1
Protein SSD1

1

0

High-throughput

0.458

High

633936

GBP2
Serine/arginine

1

0

High-throughput

0.458

High

634122

SRO9
RNA-binding protein SRO9

1

0

High-throughput

0.458

High

634873

MRC1
Mediator of replication checkpoint protein 1

1

0

High-throughput

0.458

High

636126

NOT1
General negative regulator of transcription subunit 1

1

0

High-throughput

0.458

High

664429

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.458

High

675948

XPO1
Exportin-1

1

0

High-throughput

0.458

High

691021

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.458

High

691314

NGG1
Chromatin-remodeling complexes subunit NGG1

1

0

High-throughput

0.458

High

696294

PP12
Serine/threonine-protein phosphatase PP1-2

1

0

High-throughput

0.458

High

696714

RTG1
Retrograde regulation protein 1

1

0

High-throughput

0.458

High

697374

CHD1
Chromo domain-containing protein 1

1

0

High-throughput

0.458

High

698644

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

0

High-throughput

0.458

High

703577

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

703875

PRS7
26S proteasome regulatory subunit 7 homolog

1

0

High-throughput

0.458

High

709364

LTV1
Protein LTV1

1

0

High-throughput

0.458

High

716403

YRA2
RNA annealing protein YRA2

1

0

High-throughput

0.458

High

716404

SDS22
Protein phosphatase 1 regulatory subunit SDS22

1

0

High-throughput

0.458

High

716406

YKR18
IML2-like protein YKR018C

1

0

High-throughput

0.458

High

716408

TAF5
Transcription initiation factor TFIID subunit 5

1

0

High-throughput

0.458

High

716409

MCM7
DNA replication licensing factor MCM7

1

0

High-throughput

0.458

High

716411

RTG3
Retrograde regulation protein 3

1

0

High-throughput

0.458

High

716412

RXT2
Transcriptional regulatory protein RXT2

1

0

High-throughput

0.458

High

716414

KSP1
Serine/threonine-protein kinase KSP1

1

0

High-throughput

0.458

High

716416

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

716417

RRM3
ATP-dependent DNA helicase RRM3

1

0

High-throughput

0.458

High

716418

TRA1
Transcription-associated protein 1

1

0

High-throughput

0.458

High

716423

SRP14
Signal recognition particle subunit SRP14

1

0

High-throughput

0.458

High

716428

CAJ1
Protein CAJ1

1

0

High-throughput

0.458

High

716430

CAT8
Regulatory protein CAT8

1

0

High-throughput

0.458

High

716432

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

High-throughput

0.458

High

716445

ACA2
ATF/CREB activator 2

1

0

High-throughput

0.458

High

716446

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.458

High

716449

GPD2
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial

1

0

High-throughput

0.458

High

716456

NET1
Nucleolar protein NET1

1

0

High-throughput

0.458

High

716457

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.458

High

716458

NU192
Nucleoporin NUP192

1

0

High-throughput

0.458

High

716462

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

716463

UPF3
Nonsense-mediated mRNA decay protein 3

1

0

High-throughput

0.458

High

716465

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

0

High-throughput

0.458

High

716467

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.458

High

716470

TAF6
Transcription initiation factor TFIID subunit 6

1

0

High-throughput

0.458

High

716472

SGF73
SAGA-associated factor 73

1

0

High-throughput

0.458

High

716473

SDS23
Protein SDS23

1

0

High-throughput

0.458

High

716475

SWC4
SWR1-complex protein 4

1

0

High-throughput

0.458

High

716476

YG1B
Uncharacterized protein YGR017W

1

0

High-throughput

0.458

High

716477

YG36
Uncharacterized protein YGR126W

1

0

High-throughput

0.458

High

716478

SDA1
Protein SDA1

1

0

High-throughput

0.458

High

716479

RT102
Regulator of Ty1 transposition protein 102

1

0

High-throughput

0.458

High

716480

SPC98
Spindle pole body component SPC98

1

0

High-throughput

0.458

High

716482

NRD1
Protein NRD1

1

0

High-throughput

0.458

High

716484

SNF12
Transcription regulatory protein SNF12

1

0

High-throughput

0.458

High

716485

RHO5
GTP-binding protein RHO5

1

0

High-throughput

0.458

High

716487

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.458

High

716489

H3
Histone H3

1

0

High-throughput

0.458

High

716490

ARP4
Actin-related protein 4

1

0

High-throughput

0.458

High

716492

CDC14
Tyrosine-protein phosphatase CDC14

1

0

High-throughput

0.458

High

716493

ACS1
Acetyl-coenzyme A synthetase 1

1

0

High-throughput

0.458

High

716494

GCR2
Glycolytic genes transcriptional activator GCR2

1

0

High-throughput

0.458

High

716496

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.458

High

716500

TAF12
Transcription initiation factor TFIID subunit 12

1

0

High-throughput

0.458

High

716507

YL287
Uncharacterized protein YLR287C

1

0

High-throughput

0.458

High

716508

IMB1
Importin subunit beta-1

1

0

High-throughput

0.458

High

716509

MED10
Mediator of RNA polymerase II transcription subunit 10

1

0

High-throughput

0.458

High

716510

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

High-throughput

0.458

High

716512

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

716513

YPD1
Phosphorelay intermediate protein YPD1

1

0

High-throughput

0.458

High

716514

PUF3
mRNA-binding protein PUF3

1

0

High-throughput

0.458

High

716515

RIX7
Ribosome biogenesis ATPase RIX7

1

0

High-throughput

0.458

High

716517

MED7
Mediator of RNA polymerase II transcription subunit 7

1

0

High-throughput

0.458

High

716519

TCO89
Target of rapamycin complex 1 subunit TCO89

1

0

High-throughput

0.458

High

716522

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.458

High

716523

HFI1
Transcriptional coactivator HFI1/ADA1

1

0

High-throughput

0.458

High

716524

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.458

High

716528

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.458

High

716534

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.458

High

716535

SAS5
Something about silencing protein 5

1

1

High-throughput

0.457

High

366093

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.445

High

490841

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

493638

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

694438

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.445

High

716429

XDJ1
DnaJ protein homolog XDJ1

1

2

High-throughput

0.445

High

716436

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

605971

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.438

High

716495

SPP1
COMPASS component SPP1

1

0

High-throughput

0.438

High

716516

SDO1
Ribosome maturation protein SDO1

1

0

High-throughput

0.438

High

716530

PSF1
DNA replication complex GINS protein PSF1

1

0

High-throughput

0.438

High

526116

GAL2
Galactose transporter

1

2

High-throughput

0.437

High

566563

VATA
V-type proton ATPase catalytic subunit A

1

1

High-throughput

0.437

High

629614

RV161
Reduced viability upon starvation protein 161

1

1

High-throughput

0.437

High

660902

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

1

High-throughput

0.437

High

690479

HXT3
Low-affinity glucose transporter HXT3

1

2

High-throughput

0.437

High

707832

GCN1
eIF-2-alpha kinase activator GCN1

1

1

High-throughput

0.437

High

715774

MDJ1
DnaJ homolog 1, mitochondrial

1

2

High-throughput

0.437

High

716424

HXT7
High-affinity hexose transporter HXT7

1

2

High-throughput

0.437

High

716426

TCPB
T-complex protein 1 subunit beta

1

2

High-throughput

0.437

High

716427

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.437

High

716431

RV167
Reduced viability upon starvation protein 167

1

1

High-throughput

0.437

High

716441

TCPE
T-complex protein 1 subunit epsilon

1

2

High-throughput

0.437

High

716442

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

1

High-throughput

0.437

High

716448

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.437

High

716460

BBC1
Myosin tail region-interacting protein MTI1

1

1

High-throughput

0.437

High

716483

COPA
Coatomer subunit alpha

1

1

High-throughput

0.437

High

716491

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.437

High

716501

PLP1
Phosducin-like protein 1

1

1

High-throughput

0.437

High

543516

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.407

High

381698

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.249

Low

389266

HXKA
Hexokinase-1

1

0

High-throughput

0.249

Low

423449

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.249

Low

423820

ATPA
ATP synthase subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

439550

GAL7
Galactose-1-phosphate uridylyltransferase

1

0

High-throughput

0.249

Low

446983

EI2BG
Translation initiation factor eIF2B subunit gamma

1

0

High-throughput

0.249

Low

516224

KAR1
Cell division control protein KAR1

1

0

High-throughput

0.249

Low

532775

ACOX
Acyl-coenzyme A oxidase

1

0

High-throughput

0.249

Low

540069

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.249

Low

562360

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.249

Low

568307

CAP
Adenylyl cyclase-associated protein

1

0

High-throughput

0.249

Low

578526

SEC18
Vesicular-fusion protein SEC18

1

0

High-throughput

0.249

Low

580537

FAS2
Fatty acid synthase subunit alpha

1

0

High-throughput

0.249

Low

585295

MYO2
Myosin-2

1

0

High-throughput

0.249

Low

596632

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.249

Low

619557

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.249

Low

653800

PEP3
Vacuolar membrane protein PEP3

1

0

High-throughput

0.249

Low

685505

COPG
Coatomer subunit gamma

1

0

High-throughput

0.249

Low

688965

VA0D
V-type proton ATPase subunit d

1

0

High-throughput

0.249

Low

689327

ARP2
Actin-related protein 2

1

0

High-throughput

0.249

Low

690659

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.249

Low

696441

FIMB
Fimbrin

1

0

High-throughput

0.249

Low

696779

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.249

Low

704129

CSE1
Importin alpha re-exporter

1

0

High-throughput

0.249

Low

704590

SEC3
Exocyst complex component SEC3

1

0

High-throughput

0.249

Low

704772

SLA2
Protein SLA2

1

0

High-throughput

0.249

Low

709305

NIC96
Nucleoporin NIC96

1

0

High-throughput

0.249

Low

710051

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.249

Low

716402

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.249

Low

716405

SRPB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.249

Low

716407

AKL1
Serine/threonine-protein kinase AKL1

1

0

High-throughput

0.249

Low

716413

AIM3
Altered inheritance of mitochondria protein 3

1

0

High-throughput

0.249

Low

716415

NPR3
Nitrogen permease regulator 3

1

0

High-throughput

0.249

Low

716419

BZZ1
Protein BZZ1

1

0

High-throughput

0.249

Low

716421

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

High-throughput

0.249

Low

716422

SEC31
Protein transport protein SEC31

1

0

High-throughput

0.249

Low

716425

END3
Actin cytoskeleton-regulatory complex protein END3

1

0

High-throughput

0.249

Low

716433

BEM2
GTPase-activating protein BEM2/IPL2

1

0

High-throughput

0.249

Low

716434

GTT3
Glutathione transferase 3

1

0

High-throughput

0.249

Low

716435

RPN3
26S proteasome regulatory subunit RPN3

1

0

High-throughput

0.249

Low

716437

NDH1
External NADH-ubiquinone oxidoreductase 1, mitochondrial

1

0

High-throughput

0.249

Low

716439

PEP8
Carboxypeptidase Y-deficient protein 8

1

0

High-throughput

0.249

Low

716440

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.249

Low

716443

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.249

Low

716444

GVP36
Protein GVP36

1

0

High-throughput

0.249

Low

716447

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.249

Low

716451

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.249

Low

716453

COPD
Coatomer subunit delta

1

0

High-throughput

0.249

Low

716454

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

0

High-throughput

0.249

Low

716455

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

716459

AP3S
AP-3 complex subunit sigma

1

0

High-throughput

0.249

Low

716461

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.249

Low

716464

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

716468

NU188
Nucleoporin NUP188

1

0

High-throughput

0.249

Low

716469

NBP1
NAP1-binding protein

1

0

High-throughput

0.249

Low

716471

MLC1
Myosin light chain 1

1

0

High-throughput

0.249

Low

716481

SUCA
Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

716488

DNM1
Dynamin-related protein DNM1

1

0

High-throughput

0.249

Low

716498

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.249

Low

716499

SRC1
Inner nuclear membrane protein SRC1

1

0

High-throughput

0.249

Low

716502

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

716503

IVY1
Protein IVY1

1

0

High-throughput

0.249

Low

716504

RTN1
Reticulon-like protein 1

1

0

High-throughput

0.249

Low

716505

EIS1
Eisosome protein 1

1

0

High-throughput

0.249

Low

716506

RQC1
Ribosome quality control complex subunit 1

1

0

High-throughput

0.249

Low

716511

GIC2
GTPase-interacting component 2

1

0

High-throughput

0.249

Low

716518

RPN8
26S proteasome regulatory subunit RPN8

1

0

High-throughput

0.249

Low

716520

YP225
Protein PBDC1 homolog

1

0

High-throughput

0.249

Low

716525

HSP42
Heat shock protein 42

1

0

High-throughput

0.249

Low

716526

BBP1
Spindle pole component BBP1

1

0

High-throughput

0.249

Low

716527

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.249

Low

716529

TCB1
Tricalbin-1

1

0

High-throughput

0.249

Low

716531

AVL9
Late secretory pathway protein AVL9

1

0

High-throughput

0.249

Low

716533

YI002
Uncharacterized protein YIL002W-A

1

0

High-throughput

0.249

Low

716420

PET8
Putative mitochondrial carrier protein PET8

1

0

High-throughput

0.238

Low

716450

ZIM17
Mitochondrial protein import protein ZIM17

1

0

High-throughput

0.238

Low

628952

SCJ1
DnaJ-related protein SCJ1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024