Protein: THI21
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21 (EC 2.7.1.49) (EC 2.7.4.7) (Hydroxymethylpyrimidine kinase) (HMP kinase) (Hydroxymethylpyrimidine phosphate kinase) (HMP-P kinase) (HMP-phosphate kinase) (HMPP kinase)

Gene: THI21
Organism: Saccharomyces cerevisiae S288C
Interactions: 45
UniProt ID: Q08975

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0008902 - hydroxymethylpyrimidine kinase activity
GO:0008972 - phosphomethylpyrimidine kinase activity
GO:0009228 - thiamine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

815603

RSP5
E3 ubiquitin-protein ligase RSP5

2

1

High-throughput

0.602

High

656661

KC11
Casein kinase I homolog 1

1

3

High-throughput

0.536

High

850430

ATG18
Autophagy-related protein 18

1

1

High-throughput

0.536

High

440978

CDC7
Cell division control protein 7

1

1

High-throughput

0.500

High

448596

RHO2
GTP-binding protein RHO2

1

1

High-throughput

0.500

High

533200

GPA2
Guanine nucleotide-binding protein alpha-2 subunit

1

1

High-throughput

0.500

High

574615

YAK1
Dual specificity protein kinase YAK1

1

2

High-throughput

0.500

High

671496

RAD57
DNA repair protein RAD57

1

1

High-throughput

0.500

High

746354

RAD54
DNA repair and recombination protein RAD54

1

3

High-throughput

0.500

High

802919

DBP8
ATP-dependent RNA helicase DBP8

1

2

High-throughput

0.500

High

823202

RAD26
DNA repair and recombination protein RAD26

1

3

High-throughput

0.500

High

825436

PRK1
Actin-regulating kinase PRK1

1

1

High-throughput

0.500

High

912391

UBC13
Ubiquitin-conjugating enzyme E2 13

1

2

High-throughput

0.500

High

912401

UBC11
Ubiquitin-conjugating enzyme E2-18 kDa

1

2

High-throughput

0.500

High

922183

PAP2
Poly(A) RNA polymerase protein 2

1

1

High-throughput

0.500

High

1065630

YP150
Putative serine/threonine-protein kinase YPL150W

1

3

High-throughput

0.500

High

1065628

CDC53
Cell division control protein 53

1

3

High-throughput

0.489

High

586046

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.479

High

779694

YPT53
GTP-binding protein YPT53

1

0

High-throughput

0.479

High

448478

RAD52
DNA repair and recombination protein RAD52

1

1

High-throughput

0.457

High

459178

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.457

High

550704

SIR4
Regulatory protein SIR4

1

1

High-throughput

0.457

High

598451

TUP1
General transcriptional corepressor TUP1

1

1

High-throughput

0.457

High

688828

RFA3
Replication factor A protein 3

1

1

High-throughput

0.457

High

702290

YJU2
Splicing factor YJU2

1

1

High-throughput

0.457

High

734869

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

2

High-throughput

0.457

High

808563

TEM1
Protein TEM1

1

2

High-throughput

0.457

High

825197

SDP1
Dual-specificity protein phosphatase SDP1

1

1

High-throughput

0.457

High

1026848

CDC14
Tyrosine-protein phosphatase CDC14

1

1

High-throughput

0.457

High

1037855

MEC3
DNA damage checkpoint control protein MEC3

1

1

High-throughput

0.457

High

1044286

YD131
F-box protein YDR131C

1

1

High-throughput

0.457

High

1056384

OMS1
Methyltransferase OMS1, mitochondrial

1

2

High-throughput

0.457

High

1059213

PRP11
Pre-mRNA-splicing factor PRP11

1

2

High-throughput

0.457

High

1064363

DIA2
Protein DIA2

1

1

High-throughput

0.457

High

1065629

RAD28
Radiation-sensitive protein 28

1

1

High-throughput

0.457

High

1065631

PSH1
RING finger protein PSH1

1

1

High-throughput

0.457

High

525442

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

546620

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

816456

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.445

High

1055182

PIN3
[PSI+] inducibility protein 3

1

0

High-throughput

0.282

High

1044265

WDR59
Maintenance of telomere capping protein 5

1

0

High-throughput

0.279

Low

1047300

ERB1
Ribosome biogenesis protein ERB1

1

0

High-throughput

0.279

Low

684081

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.261

Low

829832

PAC11
WD repeat-containing protein PAC11

1

0

High-throughput

0.261

Low

850056

YPI1
Type 1 phosphatases regulator YPI1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025