Protein: MED21
Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) (RNAPII complex component SRB7) (Suppressor of RNA polymerase B 7)

Gene: MED21, SRB7
Organism: Saccharomyces cerevisiae S288C
Interactions: 53
UniProt ID: P47822

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

814169

MED7
Mediator of RNA polymerase II transcription subunit 7

15

1

Small-scale

0.983

High

814168

MED10
Mediator of RNA polymerase II transcription subunit 10

8

0

Small-scale

0.917

High

814175

MED4
Mediator of RNA polymerase II transcription subunit 4

7

0

Small-scale

0.910

High

581372

MED14
Mediator of RNA polymerase II transcription subunit 14

7

0

Small-scale

0.909

High

704158

MED9
Mediator of RNA polymerase II transcription subunit 9

2

0

Small-scale

0.716

High

693554

MED17
Mediator of RNA polymerase II transcription subunit 17

7

0

Small-scale

0.713

High

748109

MED8
Mediator of RNA polymerase II transcription subunit 8

5

1

Small-scale

0.703

High

751467

MED31
Mediator of RNA polymerase II transcription subunit 31

5

0

Small-scale

0.685

High

693598

MED22
Mediator of RNA polymerase II transcription subunit 22

5

0

Small-scale

0.682

High

626039

MED19
Mediator of RNA polymerase II transcription subunit 19

5

0

Small-scale

0.679

High

693934

MED18
Mediator of RNA polymerase II transcription subunit 18

5

0

Small-scale

0.678

High

814164

MED5
Mediator of RNA polymerase II transcription subunit 5

4

0

Small-scale

0.661

High

772512

MED3
Mediator of RNA polymerase II transcription subunit 3

4

0

Small-scale

0.658

High

586320

MED15
Mediator of RNA polymerase II transcription subunit 15

4

0

Small-scale

0.653

High

814174

MED1
Mediator of RNA polymerase II transcription subunit 1

4

0

Small-scale

0.653

High

754282

MED6
Mediator of RNA polymerase II transcription subunit 6

4

0

Small-scale

0.652

High

368747

GCN4
General control transcription factor GCN4

4

0

Small-scale

0.639

High

686856

MED16
Mediator of RNA polymerase II transcription subunit 16

3

0

High-throughput

0.634

High

758001

SSN2
Mediator of RNA polymerase II transcription subunit 13

3

0

Small-scale

0.628

High

814162

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

Small-scale

0.589

High

561888

TUP1
General transcriptional corepressor TUP1

2

0

Small-scale

0.581

High

635997

SRB8
Mediator of RNA polymerase II transcription subunit 12

2

0

High-throughput

0.576

High

814171

MED2
Mediator of RNA polymerase II transcription subunit 2

2

0

High-throughput

0.576

High

381560

GAL4
Regulatory protein GAL4

2

0

Small-scale

0.561

High

814172

SCC1
Sister chromatid cohesion protein 1

2

0

High-throughput

0.561

High

760579

SSN3
Meiotic mRNA stability protein kinase SSN3

2

0

Small-scale

0.559

High

814163

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.558

High

381614

GAL80
Galactose/lactose metabolism regulatory protein GAL80

1

0

High-throughput

0.486

High

810814

IKS1
Probable serine/threonine-protein kinase IKS1

1

0

High-throughput

0.480

High

565203

KAR3
Kinesin-like protein KAR3

1

0

High-throughput

0.460

High

814167

NKP2
Inner kinetochore subunit NKP2

1

0

High-throughput

0.460

High

558138

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

662687

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

710270

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.458

High

715706

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

728277

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

751048

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.458

High

814137

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

0

High-throughput

0.458

High

814170

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.458

High

814176

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

814177

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.458

High

695043

HSP7F
Heat shock protein homolog SSE1

1

1

High-throughput

0.445

High

491742

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

511904

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

814173

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.426

High

767525

TSC11
Target of rapamycin complex 2 subunit TSC11

1

0

High-throughput

0.251

Low

773859

BNR1
BNI1-related protein 1

1

0

High-throughput

0.251

Low

814166

DAD4
DASH complex subunit DAD4

1

0

High-throughput

0.251

Low

638804

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.249

Low

629741

STE50
Protein STE50

1

0

High-throughput

0.238

Low

810463

MRX5
MIOREX complex component 5

1

0

High-throughput

0.238

Low

814165

DAM1
DASH complex subunit DAM1

1

0

Small-scale

0.238

Low


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Last updated: 15 Jul 2024