Protein: TOF1
Topoisomerase 1-associated factor 1

Gene: TOF1
Organism: Saccharomyces cerevisiae S288C
Interactions: 45
UniProt ID: P53840

Gene Ontology (top 5):
GO:0000076 - DNA replication checkpoint signaling
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006260 - DNA replication

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

923797

CSM3
Chromosome segregation in meiosis protein 3

11

0

Small-scale

0.726

High

713288

MCM5
Minichromosome maintenance protein 5

5

8

Small-scale

0.709

High

677691

MRC1
Mediator of replication checkpoint protein 1

5

0

Small-scale

0.685

High

923799

CDC45
Cell division control protein 45

4

1

Small-scale

0.683

High

917042

MCM6
DNA replication licensing factor MCM6

3

9

Small-scale

0.656

High

713014

MCM2
DNA replication licensing factor MCM2

3

8

Small-scale

0.640

High

721397

MCM4
DNA replication licensing factor MCM4

3

9

Small-scale

0.640

High

923794

SLD5
DNA replication complex GINS protein SLD5

3

1

Small-scale

0.633

High

664454

MCM3
DNA replication licensing factor MCM3

2

9

Small-scale

0.611

High

415236

TOP1
DNA topoisomerase 1

2

0

Small-scale

0.593

High

739711

SPT16
FACT complex subunit SPT16

2

0

Small-scale

0.569

High

747749

SMC1
Structural maintenance of chromosomes protein 1

1

1

Small-scale

0.561

High

864362

SMC3
Structural maintenance of chromosomes protein 3

1

1

Small-scale

0.561

High

923800

SCC1
Sister chromatid cohesion protein 1

1

0

Small-scale

0.537

High

545788

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.513

High

649549

CHL1
ATP-dependent DNA helicase CHL1

1

1

Small-scale

0.501

High

923796

POB3
FACT complex subunit POB3

1

1

Small-scale

0.501

High

359044

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

0

High-throughput

0.493

High

805983

RT107
Regulator of Ty1 transposition protein 107

1

0

Small-scale

0.486

High

826164

SCC3
Cohesin subunit SCC3

1

0

Small-scale

0.480

High

561321

DPOLA
DNA polymerase alpha catalytic subunit A

1

2

Small-scale

0.479

High

734271

DBF4
DDK kinase regulatory subunit DBF4

1

1

Small-scale

0.479

High

794090

MCM7
DNA replication licensing factor MCM7

1

7

High-throughput

0.479

High

805832

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.460

High

707810

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

709906

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

792891

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

826714

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

923795

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

923798

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

923801

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

923803

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.458

High

524744

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

527337

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

742108

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

923792

JJJ1
J protein JJJ1

1

1

High-throughput

0.445

High

579837

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.426

High

676226

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

804346

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

923793

NU100
Nucleoporin NUP100/NSP100

2

0

Small-scale

0.305

High

923802

ERV2
FAD-linked sulfhydryl oxidase ERV2

1

0

High-throughput

0.269

Low

800670

KPR2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.249

Low

752576

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

816342

HSP7E
Heat shock protein SSC3, mitochondrial

1

0

High-throughput

0.232

Low

863680

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025