Protein: MRC1
Mediator of replication checkpoint protein 1 (DNA replication checkpoint mediator MRC1)

Gene: MRC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 67
UniProt ID: P25588

Gene Ontology (top 5):
GO:0000076 - DNA replication checkpoint signaling
GO:0000723 - telomere maintenance
GO:0000781 - chromosome, telomeric region
GO:0005634 - nucleus
GO:0006260 - DNA replication

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

677664

MCM4
DNA replication licensing factor MCM4

7

4

Small-scale

0.740

High

664412

MCM3
DNA replication licensing factor MCM3

5

3

Small-scale

0.709

High

677702

CSM3
Chromosome segregation in meiosis protein 3

6

0

Small-scale

0.698

High

677662

MCM2
DNA replication licensing factor MCM2

4

3

Small-scale

0.686

High

677691

TOF1
Topoisomerase 1-associated factor 1

5

0

Small-scale

0.685

High

677709

DIA2
Protein DIA2

4

0

Small-scale

0.681

High

677707

CDC45
Cell division control protein 45

5

0

Small-scale

0.676

High

677698

SLD5
DNA replication complex GINS protein SLD5

5

0

Small-scale

0.672

High

646314

RAD53
Serine/threonine-protein kinase RAD53

4

0

Small-scale

0.651

High

665168

DPB2
DNA polymerase epsilon subunit B

3

0

Small-scale

0.625

High

677666

HOG1
Mitogen-activated protein kinase HOG1

2

0

Small-scale

0.625

High

642011

DPOE
DNA polymerase epsilon catalytic subunit A

2

0

Small-scale

0.605

High

677690

MCM6
DNA replication licensing factor MCM6

2

3

Small-scale

0.584

High

677663

MCM5
Minichromosome maintenance protein 5

2

3

Small-scale

0.571

High

677670

SMC1
Structural maintenance of chromosomes protein 1

1

1

Small-scale

0.561

High

677688

SMC3
Structural maintenance of chromosomes protein 3

1

1

Small-scale

0.561

High

677696

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

1

Small-scale

0.561

High

677667

SPT16
FACT complex subunit SPT16

2

0

Small-scale

0.559

High

677695

SEN1
Helicase SEN1

2

0

Small-scale

0.559

High

677692

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

2

0

High-throughput

0.551

High

543971

SSB1
Ribosome-associated molecular chaperone SSB1

2

0

High-throughput

0.547

High

677697

CTF4
DNA polymerase alpha-binding protein

2

0

Small-scale

0.547

High

448654

SNF1
Carbon catabolite-derepressing protein kinase

1

0

Small-scale

0.537

High

677665

PSK1
Serine/threonine-protein kinase PSK1

1

0

Small-scale

0.537

High

677684

SCC3
Cohesin subunit SCC3

1

0

Small-scale

0.537

High

677673

SPT7
SAGA complex subunit SPT7

1

0

High-throughput

0.513

High

677703

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.513

High

602338

PHO85
Cyclin-dependent protein kinase PHO85

1

1

Small-scale

0.501

High

625067

PRP9
Pre-mRNA-splicing factor PRP9

1

0

High-throughput

0.486

High

649535

CHL1
ATP-dependent DNA helicase CHL1

1

0

Small-scale

0.480

High

677676

ATR
Serine/threonine-protein kinase MEC1

1

0

Small-scale

0.480

High

677699

STE20
Serine/threonine-protein kinase STE20

1

0

Small-scale

0.480

High

677710

SCC1
Sister chromatid cohesion protein 1

1

0

Small-scale

0.480

High

364362

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.479

High

677675

CENPA
Histone H3-like centromeric protein CSE4

1

1

High-throughput

0.479

High

677677

MCM7
DNA replication licensing factor MCM7

1

1

Small-scale

0.479

High

677694

H3
Histone H3

1

1

High-throughput

0.479

High

677671

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

415203

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.458

High

594221

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

622883

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.458

High

677661

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

677669

RAD24
Checkpoint protein RAD24

1

0

Small-scale

0.458

High

677674

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

677678

RT107
Regulator of Ty1 transposition protein 107

1

0

Small-scale

0.458

High

677680

SAW1
Single-strand annealing weakened protein 1

1

0

Small-scale

0.458

High

677681

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

High-throughput

0.458

High

677683

PSF2
DNA replication complex GINS protein PSF2

1

0

Small-scale

0.458

High

677685

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

677693

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

677700

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

677701

LRS4
Monopolin complex subunit LRS4

1

0

High-throughput

0.458

High

677704

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

677708

SGO1
Shugoshin

1

0

High-throughput

0.458

High

677668

HSP7F
Heat shock protein homolog SSE1

1

1

High-throughput

0.445

High

526038

HSP72
Heat shock protein SSA2

1

0

High-throughput

0.426

High

677672

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.426

High

677679

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.426

High

677689

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.426

High

677687

GWT1
GPI-anchored wall transfer protein 1

1

0

High-throughput

0.279

Low

677682

RPN3
26S proteasome regulatory subunit RPN3

1

0

High-throughput

0.269

Low

649569

KCC2
Calcium/calmodulin-dependent protein kinase II

1

0

High-throughput

0.261

Low

677686

STB2
Protein STB2

1

0

High-throughput

0.251

Low

560149

ATR1
Aminotriazole resistance protein

1

0

High-throughput

0.249

Low

677706

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

677705

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low

677711

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025