Protein: DPOLA
DNA polymerase alpha catalytic subunit A (EC 2.7.7.7) (DNA polymerase I subunit A) (DNA polymerase alpha:primase complex p180 subunit) (DNA polymerase-primase complex p180 subunit) (Pol alpha-primase complex p180 subunit)

Gene: DPOLA, POL1
Organism: Saccharomyces cerevisiae S288C
Interactions: 70
UniProt ID: P13382

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0000510 - H3-H4 histone complex chaperone activity
GO:0000731 - DNA synthesis involved in DNA repair
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

561307

DPOA2
DNA polymerase alpha subunit B

11

5

Small-scale

0.976

High

561283

PRI2
DNA primase large subunit

5

3

Small-scale

0.916

High

561284

DPOE
DNA polymerase epsilon catalytic subunit A

3

3

Small-scale

0.857

High

561326

CTF4
DNA polymerase alpha-binding protein

14

7

Small-scale

0.765

High

521105

PRI1
DNA primase small subunit

9

4

Small-scale

0.753

High

561296

MCM4
DNA replication licensing factor MCM4

9

13

Small-scale

0.751

High

561335

CDC45
Cell division control protein 45

5

4

Small-scale

0.714

High

561329

SLD5
DNA replication complex GINS protein SLD5

10

7

Small-scale

0.686

High

561320

DPOD3
DNA polymerase delta subunit 3

3

2

Small-scale

0.668

High

561289

MCM3
DNA replication licensing factor MCM3

3

11

Small-scale

0.656

High

561333

POB3
FACT complex subunit POB3

5

3

Small-scale

0.647

High

561294

MCM2
DNA replication licensing factor MCM2

3

11

Small-scale

0.646

High

561298

MCM10
Minichromosome maintenance protein 10

3

2

Small-scale

0.646

High

561292

SPT5
Transcription elongation factor SPT5

3

1

Small-scale

0.642

High

561299

SPT16
FACT complex subunit SPT16

4

1

Small-scale

0.634

High

561337

PSF1
DNA replication complex GINS protein PSF1

4

2

Small-scale

0.633

High

561318

DPOD2
DNA polymerase delta small subunit

1

7

Small-scale

0.618

High

561295

MCM5
Minichromosome maintenance protein 5

2

11

Small-scale

0.611

High

561324

H3
Histone H3

3

7

Small-scale

0.606

High

561308

MCM7
DNA replication licensing factor MCM7

2

8

Small-scale

0.595

High

561285

RAD53
Serine/threonine-protein kinase RAD53

1

2

High-throughput

0.582

High

381833

H4
Histone H4

2

2

Small-scale

0.570

High

561290

DPB2
DNA polymerase epsilon subunit B

1

4

Small-scale

0.553

High

525786

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.536

High

380938

H2B1
Histone H2B.1

2

6

Small-scale

0.533

High

561282

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

2

High-throughput

0.533

High

561317

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.533

High

358951

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.515

High

364289

CDK1
Cyclin-dependent kinase 1

1

6

High-throughput

0.512

High

561331

CTK1
CTD kinase subunit alpha

1

5

Small-scale

0.512

High

561315

SSB2
Ribosome-associated molecular chaperone SSB2

2

10

High-throughput

0.504

High

543646

SSB1
Ribosome-associated molecular chaperone SSB1

1

10

High-throughput

0.489

High

561301

HSP7F
Heat shock protein homolog SSE1

1

13

High-throughput

0.489

High

534203

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

1

Small-scale

0.479

High

561286

RFA1
Replication factor A protein 1

1

2

High-throughput

0.479

High

561293

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

561297

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

561321

TOF1
Topoisomerase 1-associated factor 1

1

2

Small-scale

0.479

High

561325

SEN1
Helicase SEN1

1

2

Small-scale

0.479

High

561332

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

561336

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

561323

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

1

Small-scale

0.457

High

561304

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

381380

H2B2
Histone H2B.2

1

6

Small-scale

0.437

High

419340

H2A1
Histone H2A.1

1

1

Small-scale

0.437

High

438373

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

1

High-throughput

0.437

High

561287

CHL1
ATP-dependent DNA helicase CHL1

1

1

Small-scale

0.437

High

561305

CENPA
Histone H3-like centromeric protein CSE4

1

7

High-throughput

0.437

High

561309

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

1

2

Small-scale

0.437

High

561314

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

561316

PSF2
DNA replication complex GINS protein PSF2

1

1

Small-scale

0.437

High

561322

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

4

Small-scale

0.437

High

561311

MET30
F-box protein MET30

1

2

High-throughput

0.417

High

522897

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.407

High

561291

SIS1
Protein SIS1

1

5

High-throughput

0.407

High

561302

HSP79
Heat shock protein homolog SSE2

1

13

High-throughput

0.407

High

561312

TCPB
T-complex protein 1 subunit beta

1

3

High-throughput

0.407

High

561313

CAJ1
Protein CAJ1

1

4

High-throughput

0.407

High

561303

CDC13
Cell division control protein 13

5

0

Small-scale

0.376

High

561306

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

4

0

Small-scale

0.358

High

561310

POP2
Poly(A) ribonuclease POP2

2

0

High-throughput

0.324

High

550614

SIR4
Regulatory protein SIR4

1

0

Small-scale

0.261

Low

561300

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

0

Small-scale

0.261

Low

558539

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

561328

RL6A
Large ribosomal subunit protein eL6A

1

0

High-throughput

0.249

Low

561330

LIP1
Ceramide synthase subunit LIP1

1

0

High-throughput

0.249

Low

561334

CSM3
Chromosome segregation in meiosis protein 3

1

0

Small-scale

0.249

Low

561327

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.238

Low

561288

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.232

Low

561319

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025