Protein: ORC6
Origin recognition complex subunit 6 (ACS-associated protein 1) (Origin recognition complex 50 kDa subunit)

Gene: ORC6
Organism: Saccharomyces cerevisiae S288C
Interactions: 66
UniProt ID: P38826

Gene Ontology (top 5):
GO:0003688 - DNA replication origin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005656 - nuclear pre-replicative complex
GO:0005664 - nuclear origin of replication recognition complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

805520

ORC1
Origin recognition complex subunit 1

13

2

Small-scale

0.980

High

479262

CDC6
Cell division control protein 6

3

2

Small-scale

0.840

High

745646

ORC2
Origin recognition complex subunit 2

12

0

Small-scale

0.727

High

805522

ORC4
Origin recognition complex subunit 4

6

2

Small-scale

0.727

High

805521

ORC3
Origin recognition complex subunit 3

9

0

Small-scale

0.720

High

364517

CDK1
Cyclin-dependent kinase 1

7

0

Small-scale

0.717

High

805518

ORC5
Origin recognition complex subunit 5

7

0

Small-scale

0.715

High

805516

CDT1
Cell division cycle protein CDT1

6

0

Small-scale

0.699

High

718939

CGS5
S-phase entry cyclin-5

4

1

Small-scale

0.692

High

805524

CDC14
Tyrosine-protein phosphatase CDC14

4

0

Small-scale

0.673

High

805505

ORC6
Origin recognition complex subunit 6

3

0

Small-scale

0.630

High

805509

HAT2
Histone acetyltransferase type B subunit 2

3

0

Small-scale

0.622

High

805535

HAT1
Histone acetyltransferase type B catalytic subunit

3

0

Small-scale

0.622

High

712982

MCM2
DNA replication licensing factor MCM2

2

0

Small-scale

0.606

High

381512

H2B2
Histone H2B.2

2

1

High-throughput

0.601

High

544804

SSB1
Ribosome-associated molecular chaperone SSB1

2

0

High-throughput

0.576

High

381098

H2B1
Histone H2B.1

2

1

High-throughput

0.571

High

382089

H4
Histone H4

2

0

High-throughput

0.563

High

526644

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.552

High

667085

CG22
G2/mitotic-specific cyclin-2

1

1

Small-scale

0.550

High

662084

MPIP
M-phase inducer phosphatase

1

0

Small-scale

0.518

High

805537

CAF1A
Chromatin assembly factor 1 subunit A

1

0

Small-scale

0.518

High

740575

IME2
Meiosis induction protein kinase IME2/SME1

1

1

Small-scale

0.501

High

419728

H2A2
Histone H2A.2

1

0

High-throughput

0.493

High

805506

LSM12
Protein LSM12

1

0

High-throughput

0.493

High

805519

H1
Histone H1

1

0

High-throughput

0.493

High

805525

HMO1
High mobility group protein 1

1

0

High-throughput

0.493

High

805529

RRS1
Regulator of ribosome biosynthesis

1

0

High-throughput

0.493

High

805531

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.493

High

793883

PCH2
Pachytene checkpoint protein 2

1

0

Small-scale

0.480

High

448447

RAD52
DNA repair and recombination protein RAD52

1

0

Small-scale

0.460

High

557704

SRS2
ATP-dependent DNA helicase SRS2

1

0

Small-scale

0.460

High

649543

CHL1
ATP-dependent DNA helicase CHL1

1

0

Small-scale

0.460

High

734256

DBF4
DDK kinase regulatory subunit DBF4

1

0

Small-scale

0.460

High

805508

SHU2
Suppressor of hydroxyurea sensitivity protein 2

1

0

Small-scale

0.460

High

805512

CSM2
Chromosome segregation in meiosis protein 2

1

0

Small-scale

0.460

High

805528

NOC3
Nucleolar complex-associated protein 3

1

0

Small-scale

0.460

High

805532

PKH2
Serine/threonine-protein kinase PKH2

1

0

High-throughput

0.460

High

805533

PSY3
Platinum sensitivity protein 3

1

0

Small-scale

0.460

High

677389

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.458

High

805513

FKH1
Fork head protein homolog 1

1

0

Small-scale

0.458

High

805523

2ABA
Protein phosphatase PP2A regulatory subunit B

1

0

Small-scale

0.458

High

805526

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

805536

PSF1
DNA replication complex GINS protein PSF1

1

0

Small-scale

0.458

High

523883

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

741540

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

675985

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

781740

SET3
SET domain-containing protein 3

1

0

High-throughput

0.426

High

805511

RT106
Histone chaperone RTT106

1

0

High-throughput

0.426

High

805517

RL4B
Large ribosomal subunit protein uL4B

1

0

High-throughput

0.426

High

510468

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.407

High

805510

HSP7E
Heat shock protein SSC3, mitochondrial

1

2

High-throughput

0.407

High

805515

ERJ5
ER-localized J domain-containing protein 5

1

1

High-throughput

0.407

High

805527

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

4

High-throughput

0.407

High

782329

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.269

Low

675330

RAD51
DNA repair protein RAD51

1

0

Small-scale

0.251

Low

805507

RAD55
DNA repair protein RAD55

1

0

Small-scale

0.251

Low

802024

HXT5
Probable glucose transporter HXT5

1

0

High-throughput

0.249

Low

805530

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

0

High-throughput

0.249

Low

394537

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

453587

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

579350

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.232

Low

752234

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

805514

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

805534

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025