HitPredict

Interactor 1: NFKB2 (Q00653)
Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
Gene: NFKB2

Interactor 2: IKBB (Q15653)
NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)
Gene: NFKBIB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	26186194, 28514442, 33961781, 14743216, unassigned3799
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank~Ank_2, Ank_2~Ank_2, Ank_2~Ank_4, Ank_2~RHD_dimer
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 900 Hs			1 356
+	Hs
		683439 NFKB2_HUMAN (1-900): 0: 699: 100.00		IKBA_HUMAN (14-335): 5.41e-78: 243: 30.21
+	Hs
		1026696 NFKB2_HUMAN (1-900): 0: 699: 100.00		NFKB2_HUMAN (35-347): 1.92e-71: 240: 31.15
+	Hs
		127778 NFKB2_HUMAN (1-900): 0: 699: 100.00		IKBE_HUMAN (25-333): 1.22e-60: 204: 31.72
+	Mm
		682002 NFKB1_MOUSE (6-881): 0: 579: 41.13		IKBA_MOUSE (7-335): 8.96e-77: 240: 31.07
+	Hs
		626242 NFKB1_HUMAN (6-881): 0: 561: 40.69		IKBB_HUMAN (1-356): 4.61e-80: 250: 100.00
+	Hs
		626079 NFKB1_HUMAN (6-881): 0: 561: 40.69		IKBA_HUMAN (14-335): 5.41e-78: 243: 30.21
+	Mm
		682000 NFKB2_MOUSE (1-900): 0: 716: 91.78		NFKB1_MOUSE (14-140): 5.96e-11: 65.9: 29.46
+	Hs
		634918 NFKB2_HUMAN (1-900): 0: 699: 100.00		BCL3_HUMAN (49-151): 2.26e-12: 69.8: 28.16
+	Hs
		127761 NFKB1_HUMAN (6-881): 0: 561: 40.69		IKBE_HUMAN (25-333): 1.22e-60: 204: 31.72
+	Hs
		626179 NFKB2_HUMAN (1-900): 0: 699: 100.00		NFKB1_HUMAN (28-140): 2.08e-10: 64.4: 29.57
+	Mm
		681962 NFKB1_MOUSE (6-881): 0: 579: 41.13		NFKB1_MOUSE (14-140): 5.96e-11: 65.9: 29.46
+	Hs
		626062 NFKB1_HUMAN (6-881): 0: 561: 40.69		BCL3_HUMAN (49-151): 2.26e-12: 69.8: 28.16
+	Hs
		626060 NFKB1_HUMAN (6-881): 0: 561: 40.69		NFKB1_HUMAN (28-140): 2.08e-10: 64.4: 29.57
+	Hs
		626281 NFKB1_HUMAN (6-881): 0: 561: 40.69		ANKH1_HUMAN (6-91): 4.59e-10: 63.4: 16.28
+	Hs
		127780 TF65_HUMAN (24-390): 5.26e-112: 356: 37.50		IKBE_HUMAN (25-333): 1.22e-60: 204: 31.72
+	Dm
		1040521 NFKB1_DROME (8-839): 2.85e-112: 369: 23.39		CACT_DROME (147-303): 1.17e-15: 79.8: 23.60
+	Hs
		47020 A0A494C1E9_HUMAN (6-396): 4.08e-119: 373: 52.87		NFKB1_HUMAN (28-140): 2.08e-10: 64.4: 29.57
+	Hs
		626194 TF65_HUMAN (24-390): 5.26e-112: 356: 37.50		NFKB1_HUMAN (28-140): 2.08e-10: 64.4: 29.57