HitPredict

Interactor 1: APC (P25054)
Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)
Gene: APC

Interactor 2: CTNB1 (P35222)
Catenin beta-1 (Beta-catenin)
Gene: CTNNB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.994

The method score is based on:

Property Details
Experiments 26496610, 27902311, 11712088, 12628243, 11251183, 11533658, 27684187, 11707392, 32533114, 34079125, 33961781, 33858476, 19576224, 15327769, 29045831, 8259519, 11972058, 9286858, 10773885, 35271311 and 14 others

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Identification Methods affinity chromatography technology, pull down, x-ray crystallography, proximity labelling technology, unspecified method, far western blotting, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification, isothermal titration calorimetry
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains APC_15aa~Arm, APC_rep~Arm, Arm~Arm
Common GO terms GO:0001708 - cell fate specification
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005813 - centrosome
and 17 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 2843
Hs

1 781
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024