HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: SIN1 (Q9BPZ7)
Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1)
Gene: MAPKAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.721

The method score is based on:

Property	Details
Experiments	18566586, 28264193, 16962653, 21177249, 24670654
Identification Methods	enzymatic study, affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005547 - phosphatidylinositol-3,4,5-trisphosphate binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane and 5 others more... GO:0019901 - protein kinase binding GO:0030307 - positive regulation of cell growth GO:0033138 - positive regulation of peptidyl-serine phosphorylation GO:0043066 - negative regulation of apoptotic process GO:0043325 - phosphatidylinositol-3,4-bisphosphate binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	480
Hs

1	522

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024