HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: ELOB (Q15370)
Elongin-B (EloB) (Elongin 18 kDa subunit) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) (Transcription elongation factor B polypeptide 2)
Gene: ELOB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~ubiquitin, Cullin_Nedd8~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 118
+	Hs
		1043001 CUL4A_HUMAN (10-768): 0: 791: 38.32		ELOB_HUMAN (1-118): 1.64e-66: 198: 100.00
+	Hs
		1041330 CUL2_HUMAN (30-768): 0: 672: 26.17		ELOB_HUMAN (1-118): 1.64e-66: 198: 100.00
+	Hs
		1072409 CUL5_HUMAN (25-768): 0: 597: 23.77		ELOB_HUMAN (1-118): 1.64e-66: 198: 100.00
+	Ce
		105428 CUL2_CAEEL (30-768): 0: 613: 24.10		G5ECR7_CAEEL (2-108): 4.72e-45: 143: 37.17