HitPredict

Interactor 1: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Interactor 2: KLDC2 (Q9Y2U9)
Kelch domain-containing protein 2 (Hepatocellular carcinoma-associated antigen 33) (Host cell factor homolog LCP) (Host cell factor-like protein 1) (HCLP-1)
Gene: KLHDC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	16169070
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 746 Hs			1 406
+	Hs
		905412 EZH2_HUMAN (1-746): 0: 864: 100.00		HCFC1_HUMAN (3-320): 1.52e-41: 158: 19.77
+	Hs
		1155433 EZH2_HUMAN (1-746): 0: 864: 100.00		KLH12_HUMAN (6-156): 1.13e-24: 107: 16.56
+	Dm
		837337 EZ_DROME (8-745): 0: 714: 52.70		Q9W3D5_DROME (5-160): 7.31e-27: 112: 19.50
+	Zm
		35532 A0A1D6LLI6_MAIZE (223-733): 5.24e-103: 340: 25.77		A0A1D6PPA8_MAIZE (113-369): 1.76e-35: 140: 17.98
+	Mm
		936633 KMT2A_MOUSE (298-733): 5.15e-77: 273: 18.00		HCFC1_MOUSE (3-320): 1.06e-41: 159: 20.06
+	Hs
		216568 SUV91_HUMAN (354-731): 2.69e-71: 240: 19.90		KLH20_HUMAN (165-406): 3.17e-50: 180: 13.17
+	Hs
		1328763 EHMT1_HUMAN (441-732): 1.63e-70: 253: 24.27		LZTR1_HUMAN (238-405): 3.62e-28: 119: 13.79
+	Hs
		216527 SUV91_HUMAN (354-731): 2.69e-71: 240: 19.90		KLDC3_HUMAN (5-198): 5.29e-29: 118: 16.84
+	Hs
		1348606 SUV92_HUMAN (447-734): 5.91e-74: 247: 24.10		KLDC4_HUMAN (7-259): 6.87e-13: 72.1: 19.93
+	Hs
		216496 SUV91_HUMAN (354-731): 2.69e-71: 240: 19.90		KLDC4_HUMAN (7-259): 6.87e-13: 72.1: 19.93
+	Hs
		905384 KMT2A_HUMAN (606-733): 6.92e-19: 94.4: 39.54		HCFC1_HUMAN (3-320): 1.52e-41: 158: 19.77
+	Hs
		905515 SET1B_HUMAN (619-732): 1.39e-18: 93.2: 40.52		HCFC1_HUMAN (3-320): 1.52e-41: 158: 19.77
+	Hs
		175860 SET1A_HUMAN (611-732): 3.2e-18: 92: 38.71		HCFC1_HUMAN (3-320): 1.52e-41: 158: 19.77
+	Dm
		1208006 SET1_DROME (611-732): 1.28e-18: 93.2: 38.71		HCF_DROME (3-304): 2.27e-40: 155: 19.48
+	Dm
		1306741 TRR_DROME (611-732): 1.54e-18: 93.2: 40.65		HCF_DROME (3-304): 2.27e-40: 155: 19.48
+	Hs
		1041631 KMT2A_HUMAN (606-733): 6.92e-19: 94.4: 39.54		HCFC2_HUMAN (132-404): 2.85e-26: 113: 17.85
+	Hs
		1462559 SET1B_HUMAN (619-732): 1.39e-18: 93.2: 40.52		HCFC2_HUMAN (132-404): 2.85e-26: 113: 17.85
+	Hs
		175957 SET1A_HUMAN (611-732): 3.2e-18: 92: 38.71		HCFC2_HUMAN (132-404): 2.85e-26: 113: 17.85