HitPredict

Interactor 1: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Interactor 2: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 0.60 0.764

The method score is based on:

Property Details
Experiments 14701753, 20473329, 11453982, 9632795, 23612964, 24728074, 11940581, 9658397, 9804835, 14982882, 11027663, 24935154, 12855672, 14665621, 11323411, 15574420, 20308328
Identification Methods affinity chromatography technology, unspecified method, pull down, two hybrid, far western blotting, anti tag coimmunoprecipitation, phosphatase assay, coimmunoprecipitation, anti bait coimmunoprecipitation, surface plasmon resonance and 1 others

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Interaction Type physical association, direct interaction, dephosphorylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007173 - epidermal growth factor receptor signaling pathway
GO:0042311 - vasodilation
GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
and 1 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 11Aug2025