Interactor 1: ITPR3 (Q14573)
Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)
Gene: ITPR3

Interactor 2: TRPC6 (Q9Y210)
Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6)
Gene: TRPC6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 11290752, 10611319
Identification Methods pull down, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Ion_trans~Ion_trans
Common GO terms GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0007204 - positive regulation of cytosolic calcium ion concentration
GO:0016020 - membrane
GO:0070679 - inositol 1,4,5 trisphosphate binding
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 2671
Hs

1 931
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024