HitPredict

Interactor 1: LZTS2 (Q9BRK4)
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Gene: LZTS2

Interactor 2: SHAN3 (Q9BYB0)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Gene: SHANK3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 669 Hs			1 1731
+	Hs
		165779 N4BP3_HUMAN (17-640): 5.23e-34: 139: 27.16		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		230552 LZTS3_HUMAN (1-669): 7.26e-32: 133: 31.62		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Mm
		1116130 TSC1_MOUSE (48-630): 3.36e-32: 135: 13.67		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Hs
		1078902 ITSN1_HUMAN (75-640): 4.07e-22: 104: 13.88		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1316306 EP15R_HUMAN (483-668): 6.69e-11: 67.8: 12.90		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Mm
		139888 DCTN1_MOUSE (88-572): 4.8e-12: 71.6: 11.02		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Mm
		1115981 MRCKB_MOUSE (200-560): 2.02e-11: 69.7: 12.40		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Mm
		1161349 TSC1_MOUSE (48-630): 3.36e-32: 135: 13.67		TNKS1_MOUSE (16-429): 9.56e-82: 298: 13.45
+	Hs
		1021450 LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00		ANK3_HUMAN (120-561): 2.39e-41: 170: 15.54
+	Hs
		166927 DCTN1_HUMAN (88-572): 2.4e-12: 72.7: 10.41		ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48
+	Hs
		166947 CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52		ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48
+	Rn
		251022 PLEC_RAT (325-643): 5.59e-09: 61.9: 20.30		ANK3_RAT (11-639): 1.19e-61: 236: 14.61
+	Mm
		88377 TSC1_MOUSE (48-630): 3.36e-32: 135: 13.67		SHAN1_MOUSE (323-1726): 7.25e-25: 115: 13.87
+	Hs
		1237564 MTCL1_HUMAN (56-644): 5.72e-34: 141: 14.24		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Hs
		1021469 EP15R_HUMAN (483-668): 6.69e-11: 67.8: 12.90		ANK3_HUMAN (120-561): 2.39e-41: 170: 15.54
+	Hs
		1021404 PLEC_HUMAN (327-659): 1.61e-09: 63.5: 20.77		ANK3_HUMAN (120-561): 2.39e-41: 170: 15.54
+	Hs
		1051366 DCTN1_HUMAN (88-572): 2.4e-12: 72.7: 10.41		ANR52_HUMAN (1-202): 2.56e-32: 139: 10.58
+	Hs
		1078859 ITSN1_HUMAN (75-640): 4.07e-22: 104: 13.88		MIB1_HUMAN (129-324): 9.56e-15: 82: 32.50
+	Hs
		1206081 EP15R_HUMAN (483-668): 6.69e-11: 67.8: 12.90		MIB1_HUMAN (129-324): 9.56e-15: 82: 32.50
+	Hs
		1145819 CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52		MIB1_HUMAN (129-324): 9.56e-15: 82: 32.50