HitPredict

Interactor 1: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Interactor 2: EPS8 (Q12929)
Epidermal growth factor receptor kinase substrate 8
Gene: EPS8

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	14565974, 27629044, 10499589, 16520382
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RhoGEF~SH3_1, SH3_1~SOS1_NGEF_PH
Common GO terms	GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1333 Hs			1 822
+	Mm
		1064405 SOS1_MOUSE (1-1333): 0: 965: 96.47		EPS8_MOUSE (1-822): 0: 956: 89.05
+	Hs
		1060696 SOS1_HUMAN (1-1333): 0: 1000: 100.00		ES8L2_HUMAN (7-811): 0: 769: 40.67
+	Hs
		1060686 SOS1_HUMAN (1-1333): 0: 1000: 100.00		ES8L1_HUMAN (29-805): 0: 717: 35.60
+	Hs
		855855 SOS1_HUMAN (1-1333): 0: 1000: 100.00		CRKL_HUMAN (487-662): 3.09e-33: 132: 20.79
+	Hs
		440511 SOS1_HUMAN (1-1333): 0: 1000: 100.00		FYN_HUMAN (454-613): 1.08e-27: 120: 16.57
+	Hs
		855598 SOS1_HUMAN (1-1333): 0: 1000: 100.00		CRK_HUMAN (487-661): 8.46e-28: 116: 18.75
+	Hs
		109541 G5E9C8_HUMAN (1-1333): 0: 982: 98.65		CRKL_HUMAN (487-662): 3.09e-33: 132: 20.79
+	Mm
		868839 SOS1_MOUSE (1-1333): 0: 965: 96.47		CRKL_MOUSE (487-662): 4.55e-32: 128: 19.10
+	Hs
		593974 SOS1_HUMAN (1-1333): 0: 1000: 100.00		NCK1_HUMAN (536-621): 1.03e-18: 90.8: 30.23
+	Rn
		93231 D4A3T0_RAT (1-1333): 0: 966: 96.40		PACN1_RAT (435-586): 2.51e-27: 118: 17.53
+	Hs
		222064 SOS1_HUMAN (1-1333): 0: 1000: 100.00		NCK2_HUMAN (535-612): 1.03e-12: 72.7: 24.69
+	Hs
		855856 SOS2_HUMAN (1-1131): 0: 858: 73.59		CRKL_HUMAN (487-662): 3.09e-33: 132: 20.79
+	Hs
		440512 SOS2_HUMAN (1-1131): 0: 858: 73.59		FYN_HUMAN (454-613): 1.08e-27: 120: 16.57
+	Hs
		855599 SOS2_HUMAN (1-1131): 0: 858: 73.59		CRK_HUMAN (487-661): 8.46e-28: 116: 18.75
+	Hs
		593975 SOS2_HUMAN (1-1131): 0: 858: 73.59		NCK1_HUMAN (536-621): 1.03e-18: 90.8: 30.23
+	Hs
		222065 SOS2_HUMAN (1-1131): 0: 858: 73.59		NCK2_HUMAN (535-612): 1.03e-12: 72.7: 24.69
+	Dm
		688363 SOS_DROME (8-1333): 0: 704: 41.74		SRC42_DROME (501-594): 1.9e-14: 78.8: 23.23
+	Hs
		440548 RPGF1_HUMAN (571-1032): 2.17e-92: 324: 23.63		FYN_HUMAN (454-613): 1.08e-27: 120: 16.57
+	Mm
		1225138 Q91ZZ2_MOUSE (599-1020): 2.19e-92: 325: 25.12		CRK_MOUSE (487-661): 1.51e-27: 115: 18.75
+	Hs
		593989 RPGF1_HUMAN (571-1032): 2.17e-92: 324: 23.63		NCK1_HUMAN (536-621): 1.03e-18: 90.8: 30.23