Protein: ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1)

Gene: ES8L1, EPS8L1
Organism: Homo sapiens
Interactions: 56
UniProt ID: Q8TE68

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007266 - Rho protein signal transduction
GO:0032587 - ruffle membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1352135

ABI2
Abl interactor 2

4

20

High-throughput

0.890

High

1316682

ABI1
Abl interactor 1

3

20

Small-scale

0.839

High

1352139

BAIP2
BAR/IMD domain-containing adapter protein 2

2

16

High-throughput

0.776

High

1256682

RHG27
Rho GTPase-activating protein 27

1

20

High-throughput

0.691

High

460272

CD3E
T-cell surface glycoprotein CD3 epsilon chain

2

6

Small-scale

0.654

High

1352125

CDK15
Cyclin-dependent kinase 15

2

13

High-throughput

0.628

High

1352127

NUD12
NAD-capped RNA hydrolase NUDT12

1

16

High-throughput

0.618

High

1060686

SOS1
Son of sevenless homolog 1

1

20

Small-scale

0.618

High

70379

CRTP1
Cysteine-rich tail protein 1

2

2

High-throughput

0.606

High

1272182

CYFP1
Cytoplasmic FMR1-interacting protein 1

2

13

High-throughput

0.601

High

1352121

BRK1
Protein BRICK1

2

2

High-throughput

0.601

High

1352124

CYFP2
Cytoplasmic FMR1-interacting protein 2

2

13

High-throughput

0.601

High

1352140

NCKP1
Nck-associated protein 1

2

3

High-throughput

0.601

High

1352144

WASF2
Actin-binding protein WASF2

2

16

High-throughput

0.601

High

881799

DHYS
Deoxyhypusine synthase

2

0

High-throughput

0.576

High

1351366

DLG5
Disks large homolog 5

1

19

High-throughput

0.575

High

1352133

TB22B
TBC1 domain family member 22B

2

3

High-throughput

0.574

High

1352132

ADA19
Disintegrin and metalloproteinase domain-containing protein 19

1

20

Small-scale

0.536

High

733399

CCR1
C-C chemokine receptor type 1

1

9

High-throughput

0.536

High

943100

STX17
Syntaxin-17

1

2

High-throughput

0.536

High

1058163

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

High-throughput

0.536

High

1332790

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.536

High

1352122

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

2

High-throughput

0.536

High

1352123

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

15

High-throughput

0.536

High

1352131

SRRT
Serrate RNA effector molecule homolog

1

1

High-throughput

0.536

High

1250390

DPP8
Dipeptidyl peptidase 8

1

4

High-throughput

0.515

High

231741

PEX1
Peroxisomal ATPase PEX1

1

1

High-throughput

0.515

High

705483

GRN
Progranulin

1

1

High-throughput

0.515

High

843799

HD
Huntingtin

1

5

High-throughput

0.515

High

575172

IDE
Insulin-degrading enzyme

1

0

High-throughput

0.513

High

1023840

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

1006578

SRPK2
SRSF protein kinase 2

1

13

High-throughput

0.501

High

325337

OR2A4
Olfactory receptor 2A4

1

1

High-throughput

0.489

High

1352141

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.489

High

556236

CADH1
Cadherin-1

1

11

High-throughput

0.479

High

872565

SOX2
Transcription factor SOX-2

1

5

High-throughput

0.479

High

934900

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.479

High

993259

ACTG
Actin, cytoplasmic 2

1

8

Small-scale

0.479

High

301592

WFS1
Wolframin

1

2

High-throughput

0.470

High

261228

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.445

High

1056870

FMR1
Fragile X messenger ribonucleoprotein 1

1

8

High-throughput

0.445

High

1227126

A16L1
Autophagy-related protein 16-1

1

13

High-throughput

0.445

High

1270479

MARK2
Serine/threonine-protein kinase MARK2

1

11

High-throughput

0.445

High

1352136

MARK1
Serine/threonine-protein kinase MARK1

1

11

High-throughput

0.445

High

1352138

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

12

High-throughput

0.445

High

1312468

PHC2
Polyhomeotic-like protein 2

1

11

High-throughput

0.407

High

1352128

BUD13
BUD13 homolog

1

2

High-throughput

0.407

High

1352130

RSRP1
Arginine/serine-rich protein 1

1

1

High-throughput

0.407

High

1352137

NHSL3
NHS-like protein 3

1

20

High-throughput

0.407

High

1352134

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.299

High

1181329

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

1292325

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.279

Low

1352126

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

1352129

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

1352142

RRP7A
Ribosomal RNA-processing protein 7 homolog A

1

0

High-throughput

0.232

Low

1352143

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025