HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: SOS2 (Q07890)
Son of sevenless homolog 2 (SOS-2)
Gene: SOS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	RhoGEF~SH3_1, SH3_1~SOS1_NGEF_PH
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 1332
+	Hs
		593975 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		SOS2_HUMAN (1-1332): 0: 947: 100.00
+	Hs
		222064 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		SOS1_HUMAN (1-1331): 0: 897: 67.61
+	Hs
		593974 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		SOS1_HUMAN (1-1331): 0: 897: 67.61
+	Hs
		1060722 ITSN2_HUMAN (5-273): 6.53e-36: 141: 19.27		SOS2_HUMAN (1-1332): 0: 947: 100.00
+	Hs
		1060709 ITSN1_HUMAN (5-253): 2.96e-28: 119: 16.61		SOS2_HUMAN (1-1332): 0: 947: 100.00
+	Hs
		699713 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		SOS2_HUMAN (1-1332): 0: 947: 100.00
+	Hs
		1060697 ITSN2_HUMAN (5-273): 6.53e-36: 141: 19.27		SOS1_HUMAN (1-1331): 0: 897: 67.61
+	Hs
		1060677 ITSN1_HUMAN (5-253): 2.96e-28: 119: 16.61		SOS1_HUMAN (1-1331): 0: 897: 67.61
+	Hs
		1060675 GRAP_HUMAN (5-169): 9.9e-28: 110: 15.74		SOS1_HUMAN (1-1331): 0: 897: 67.61
+	Hs
		699712 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		SOS1_HUMAN (1-1331): 0: 897: 67.61
+	Hs
		473405 HCK_HUMAN (2-184): 1.58e-23: 103: 21.74		SOS1_HUMAN (1-1331): 0: 897: 67.61
+	Hs
		594071 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		ARHG2_HUMAN (30-849): 7.3e-100: 344: 11.51
+	Hs
		593989 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		RPGF1_HUMAN (571-1020): 8.81e-96: 334: 25.99
+	Hs
		594064 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		RPGF5_HUMAN (616-1017): 1.53e-80: 278: 18.38
+	Hs
		699741 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		RPGF1_HUMAN (571-1020): 8.81e-96: 334: 25.99
+	Hs
		473415 HCK_HUMAN (2-184): 1.58e-23: 103: 21.74		RPGF1_HUMAN (571-1020): 8.81e-96: 334: 25.99
+	Hs
		1154138 ITSN1_HUMAN (5-253): 2.96e-28: 119: 16.61		PREX1_HUMAN (155-695): 6.22e-82: 298: 16.33
+	Hs
		584478 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		VAV_HUMAN (54-665): 1.37e-86: 303: 13.04
+	Hs
		594015 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		RGPS1_HUMAN (772-936): 3.58e-19: 95.1: 30.41
+	Hs
		238796 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		KALRN_HUMAN (8-626): 8.99e-65: 245: 11.41