HitPredict

Interactor 1: TWF1 (Q12792)
Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9)
Gene: TWF1

Interactor 2: ARP10 (Q9NZ32)
Actin-related protein 10 (Actin-related protein 11) (hARP11)
Gene: ACTR10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 350 Hs			1 417
+	Hs
		952782 TWF1_HUMAN (1-350): 5.69e-171: 481: 100.00		ACTB_HUMAN (10-384): 3.64e-173: 490: 23.94
+	Hs
		993148 TWF1_HUMAN (1-350): 5.69e-171: 481: 100.00		ACTG_HUMAN (10-384): 3.05e-173: 490: 24.44
+	Hs
		995558 TWF1_HUMAN (1-350): 5.69e-171: 481: 100.00		ACTC_HUMAN (7-384): 7.64e-172: 487: 24.51
+	Hs
		952893 TWF2_HUMAN (1-344): 3.8e-159: 451: 65.41		ACTB_HUMAN (10-384): 3.64e-173: 490: 23.94
+	Hs
		993215 TWF2_HUMAN (1-344): 3.8e-159: 451: 65.41		ACTG_HUMAN (10-384): 3.05e-173: 490: 24.44
+	Hs
		995646 TWF2_HUMAN (1-344): 3.8e-159: 451: 65.41		ACTC_HUMAN (7-384): 7.64e-172: 487: 24.51
+	Hs
		977727 TWF2_HUMAN (1-344): 3.8e-159: 451: 65.41		ACTA_HUMAN (7-384): 5.83e-171: 484: 24.26
+	Dm
		534474 TWF_DROME (1-344): 2.48e-146: 418: 48.84		ACT1_DROME (8-384): 2.78e-173: 491: 24.57
+	Dm
		1014451 TWF_DROME (1-344): 2.48e-146: 418: 48.84		ACT6_DROME (8-383): 1.05e-171: 486: 24.88
+	Sc
		918592 TWF1_YEAST (1-334): 4.12e-86: 264: 24.65		ACT_YEAST (10-384): 2.54e-170: 483: 23.94
+	Ce
		534403 ADF1_CAEEL (4-189): 4.07e-42: 147: 17.23		ACT4_CAEEL (8-384): 1.72e-173: 491: 24.57
+	At
		920953 ADF6_ARATH (5-139): 1.36e-45: 154: 23.19		ACT7_ARATH (7-384): 1.03e-169: 481: 23.76
+	Hs
		952698 GMFB_HUMAN (178-312): 1.21e-41: 144: 21.43		ACTB_HUMAN (10-384): 3.64e-173: 490: 23.94
+	Hs
		955875 GMFB_HUMAN (178-312): 1.21e-41: 144: 21.43		ACTG_HUMAN (10-384): 3.05e-173: 490: 24.44
+	Hs
		952697 DEST_HUMAN (4-138): 2.64e-40: 141: 18.59		ACTB_HUMAN (10-384): 3.64e-173: 490: 23.94
+	Sc
		948633 COFI_YEAST (1-142): 2.09e-42: 146: 22.60		ACT_YEAST (10-384): 2.54e-170: 483: 23.94
+	Sp
		534533 COFI_SCHPO (5-141): 7.28e-42: 144: 24.46		ACT_SCHPO (10-383): 1.29e-170: 484: 24.25
+	At
		509991 ADF4_ARATH (3-139): 5.6e-50: 165: 25.00		ACT1_ARATH (7-382): 2.56e-32: 127: 24.88
+	At
		509990 ADF6_ARATH (5-139): 1.36e-45: 154: 23.19		ACT1_ARATH (7-382): 2.56e-32: 127: 24.88
+	At
		509993 ADF6_ARATH (5-139): 1.36e-45: 154: 23.19		ACT3_ARATH (7-382): 2.56e-32: 127: 24.88