HitPredict

Interactor 1: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Interactor 2: SH3G2 (Q99962)
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
Gene: SH3GL2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	21900206
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH3_2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 533 Hs			1 352
+	Mm
		1224157 BLNK_MOUSE (78-520): 1.12e-35: 140: 23.27		SH3G1_MOUSE (1-352): 6.12e-84: 260: 69.02
+	Hs
		215946 SYNJ1_HUMAN (10-452): 3.63e-12: 71.6: 11.37		SH3G2_HUMAN (1-352): 4.28e-96: 291: 100.00
+	Rn
		204410 SYNJ1_RAT (28-428): 2.29e-10: 65.8: 13.29		SH3G2_RAT (1-352): 1.56e-95: 289: 98.58
+	Rn
		204412 SYNJ1_RAT (28-428): 2.29e-10: 65.8: 13.29		SH3G3_RAT (1-352): 4.39e-88: 270: 65.91
+	Hs
		215945 SYNJ1_HUMAN (10-452): 3.63e-12: 71.6: 11.37		SH3G1_HUMAN (1-352): 9.12e-85: 262: 69.57
+	Hs
		1094306 LCP2_HUMAN (1-533): 2.39e-78: 257: 100.00		SH3R1_HUMAN (287-346): 1.49e-12: 70.9: 42.19
+	Hs
		987600 LCP2_HUMAN (1-533): 2.39e-78: 257: 100.00		GRB2_HUMAN (295-351): 1.52e-12: 67.8: 43.10
+	Mm
		1221218 LCP2_MOUSE (1-531): 1.4e-72: 242: 80.98		GRB2_MOUSE (295-351): 1.72e-12: 67.8: 43.10
+	Hs
		1361944 TITIN_HUMAN (65-384): 2.15e-11: 69.3: 12.27		SHLB1_HUMAN (10-347): 9.95e-72: 229: 24.50
+	Hs
		987739 CLNK_HUMAN (182-528): 9.86e-42: 156: 25.00		GRB2_HUMAN (295-351): 1.52e-12: 67.8: 43.10
+	Hs
		635544 TITIN_HUMAN (65-384): 2.15e-11: 69.3: 12.27		NEBU_HUMAN (7-347): 2.86e-36: 142: 16.06
+	Mm
		1341639 BLNK_MOUSE (78-520): 1.12e-35: 140: 23.27		SH3K1_MOUSE (280-347): 3.74e-10: 63.2: 44.00
+	Hs
		987798 BLNK_HUMAN (75-520): 1.01e-33: 135: 24.28		GRB2_HUMAN (295-351): 1.52e-12: 67.8: 43.10
+	Mm
		236367 O54737_MOUSE (52-523): 4.08e-31: 128: 19.92		GRB2_MOUSE (295-351): 1.72e-12: 67.8: 43.10
+	Hs
		987699 TENS2_HUMAN (76-512): 1.92e-30: 128: 17.42		GRB2_HUMAN (295-351): 1.52e-12: 67.8: 43.10
+	Hs
		987833 PRG4_HUMAN (17-470): 2.47e-14: 78.5: 13.95		GRB2_HUMAN (295-351): 1.52e-12: 67.8: 43.10
+	Hs
		215925 SYNJ1_HUMAN (10-452): 3.63e-12: 71.6: 11.37		ITSN1_HUMAN (269-349): 1.86e-12: 70.8: 23.46
+	Hs
		215914 SYNJ1_HUMAN (10-452): 3.63e-12: 71.6: 11.37		GRB2_HUMAN (295-351): 1.52e-12: 67.8: 43.10
+	Hs
		215886 SYNJ1_HUMAN (10-452): 3.63e-12: 71.6: 11.37		SRBS2_HUMAN (296-347): 7.73e-10: 62.4: 51.92
+	Hs
		215927 SYNJ1_HUMAN (10-452): 3.63e-12: 71.6: 11.37		SH319_HUMAN (296-347): 6.78e-10: 62.4: 55.77