HitPredict

Interactor 1: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Interactor 2: BLNK (Q8WV28)
B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)
Gene: BLNK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0035556 - intracellular signal transduction GO:0035591 - signaling adaptor activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 694 Hs			1 456
+	Hs
		136383 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		P85B_HUMAN (129-453): 1.24e-44: 168: 17.05
+	Hs
		699736 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Mm
		686988 GAB1_MOUSE (1-694): 3.64e-172: 510: 89.93		P85A_MOUSE (121-453): 4.28e-43: 163: 14.41
+	Hs
		1106496 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		P55G_HUMAN (327-453): 3.33e-27: 115: 24.41
+	Hs
		1106482 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		TENS3_HUMAN (10-436): 9.11e-25: 109: 15.25
+	Mm
		1282037 GAB1_MOUSE (1-694): 3.64e-172: 510: 89.93		Q80UI5_MOUSE (341-453): 2.49e-25: 109: 27.43
+	Hs
		1106510 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		TENS1_HUMAN (18-436): 4.15e-23: 105: 14.61
+	Hs
		1106490 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		TENS4_HUMAN (81-436): 3.71e-20: 95.6: 13.70
+	Hs
		136450 GAB2_HUMAN (3-691): 1.85e-144: 438: 38.73		P85B_HUMAN (129-453): 1.24e-44: 168: 17.05
+	Hs
		699899 GAB2_HUMAN (3-691): 1.85e-144: 438: 38.73		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Mm
		148483 GAB2_MOUSE (3-691): 3.12e-131: 404: 38.05		P85B_MOUSE (131-453): 3.38e-43: 163: 16.27
+	Mm
		148477 Q3ZB59_MOUSE (3-691): 6.68e-131: 403: 38.05		P85B_MOUSE (131-453): 3.38e-43: 163: 16.27
+	Mm
		686964 Q3ZB59_MOUSE (3-691): 6.68e-131: 403: 38.05		P85A_MOUSE (121-453): 4.28e-43: 163: 14.41
+	Hs
		1364896 GAB2_HUMAN (3-691): 1.85e-144: 438: 38.73		P55G_HUMAN (327-453): 3.33e-27: 115: 24.41
+	Hs
		1359843 GAB3_HUMAN (1-683): 9.25e-96: 309: 28.39		P55G_HUMAN (327-453): 3.33e-27: 115: 24.41
+	Hs
		215931 PKHA7_HUMAN (5-485): 2.19e-62: 227: 11.88		SYNJ1_HUMAN (40-436): 8.68e-25: 110: 12.71
+	Hs
		1211247 PKHS1_HUMAN (5-310): 1.68e-41: 159: 16.31		P55G_HUMAN (327-453): 3.33e-27: 115: 24.41
+	Hs
		925753 PKHA2_HUMAN (2-194): 4.15e-35: 140: 20.77		SC24C_HUMAN (93-403): 1.41e-23: 106: 12.23
+	Dm
		119660 M9PB30_DROME (119-687): 2.62e-13: 76: 12.77		M9PB30_DROME (25-304): 2.2e-09: 62.1: 10.99