HitPredict

Interactor 1: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Interactor 2: SLAP2 (Q9H6Q3)
Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2)
Gene: SLA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0035591 - signaling adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 694 Hs			1 261
+	Hs
		473414 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		HCK_HUMAN (8-259): 1.17e-81: 256: 30.53
+	Hs
		463507 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		LYN_HUMAN (6-257): 8.25e-80: 250: 31.27
+	Hs
		440063 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		LCK_HUMAN (2-259): 4.75e-79: 248: 30.57
+	Hs
		463085 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		YES_HUMAN (33-259): 1.23e-78: 248: 31.92
+	Hs
		902834 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		BLK_HUMAN (2-259): 9.99e-78: 245: 30.88
+	Hs
		557285 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		SRC_HUMAN (13-259): 5.24e-77: 244: 30.98
+	Mm
		431376 GAB1_MOUSE (1-694): 3.64e-172: 510: 89.93		SRC_MOUSE (13-259): 5.88e-77: 244: 30.98
+	Hs
		1054106 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		BTK_HUMAN (10-260): 4.1e-65: 216: 21.46
+	Hs
		1065081 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		ITK_HUMAN (8-260): 1.13e-64: 214: 22.56
+	Hs
		840880 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		TEC_HUMAN (7-260): 3.13e-63: 210: 21.81
+	Hs
		1106474 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		PTK6_HUMAN (26-251): 1.55e-58: 194: 22.88
+	Hs
		1098881 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		SLAP1_HUMAN (13-259): 3.57e-60: 193: 38.49
+	Hs
		463850 GAB2_HUMAN (3-691): 1.85e-144: 438: 38.73		LYN_HUMAN (6-257): 8.25e-80: 250: 31.27
+	Hs
		557534 GAB2_HUMAN (3-691): 1.85e-144: 438: 38.73		SRC_HUMAN (13-259): 5.24e-77: 244: 30.98
+	Hs
		292833 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		GRAP2_HUMAN (37-176): 3.4e-15: 75.9: 37.14
+	Mm
		313438 GAB1_MOUSE (1-694): 3.64e-172: 510: 89.93		GRAP2_MOUSE (37-176): 1.25e-13: 71.2: 35.71
+	Hs
		987613 GAB1_HUMAN (1-694): 6.33e-173: 512: 100.00		GRB2_HUMAN (37-176): 3.7e-13: 68.6: 32.39
+	Mm
		1221262 GAB1_MOUSE (1-694): 3.64e-172: 510: 89.93		GRB2_MOUSE (37-176): 3.7e-13: 68.6: 32.39
+	Hs
		292883 GAB2_HUMAN (3-691): 1.85e-144: 438: 38.73		GRAP2_HUMAN (37-176): 3.4e-15: 75.9: 37.14
+	Hs
		988039 GAB2_HUMAN (3-691): 1.85e-144: 438: 38.73		GRB2_HUMAN (37-176): 3.7e-13: 68.6: 32.39