HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: PF21A (Q96BD5)
PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80)
Gene: PHF21A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	12032298, 34709266, 26496610, 28514442, 15325272, 33961781, 35271311, 23752268, unassigned3799
Identification Methods	biochemical, proximity labelling technology, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	association, physical association, direct interaction

Property	Details
Interacting Pfam domains	Hist_deacetyl~PHD
Common GO terms	GO:0000118 - histone deacetylase complex GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Hs			1 680
+	Hs
		180806 HDAC1_HUMAN (1-482): 0: 668: 100.00		TIF1A_HUMAN (2-647): 2.12e-79: 275: 14.56
+	Hs
		180886 HDAC2_HUMAN (1-478): 0: 666: 85.92		TIF1A_HUMAN (2-647): 2.12e-79: 275: 14.56
+	Hs
		1110151 HDAC1_HUMAN (1-482): 0: 668: 100.00		KDM5B_HUMAN (147-656): 1.24e-63: 231: 14.04
+	Mm
		148715 HDAC1_MOUSE (1-482): 0: 672: 99.38		KDM5B_MOUSE (139-656): 1.1e-61: 225: 14.96
+	Hs
		833733 HDAC1_HUMAN (1-482): 0: 668: 100.00		KDM5C_HUMAN (164-655): 1.21e-62: 228: 15.98
+	Hs
		711818 HDAC1_HUMAN (1-482): 0: 668: 100.00		KDM5A_HUMAN (211-656): 2.13e-53: 201: 16.59
+	Hs
		1110160 HDAC1_HUMAN (1-482): 0: 668: 100.00		BAZ2A_HUMAN (4-648): 2.66e-53: 200: 11.71
+	Hs
		711837 HDAC2_HUMAN (1-478): 0: 666: 85.92		KDM5A_HUMAN (211-656): 2.13e-53: 201: 16.59
+	Mm
		59097 HDAC1_MOUSE (1-482): 0: 672: 99.38		CHD5_MOUSE (255-617): 9.73e-48: 184: 16.33
+	Mm
		148708 HDAC1_MOUSE (1-482): 0: 672: 99.38		CHD4_MOUSE (255-650): 9.38e-43: 168: 14.51
+	Hs
		1109925 HDAC1_HUMAN (1-482): 0: 668: 100.00		CHD5_HUMAN (255-617): 1.44e-43: 171: 16.79
+	Hs
		1109728 HDAC1_HUMAN (1-482): 0: 668: 100.00		CHD4_HUMAN (255-650): 3.89e-43: 170: 14.51
+	Hs
		1088327 HDAC1_HUMAN (1-482): 0: 668: 100.00		CHD3_HUMAN (297-617): 2.53e-41: 164: 16.57
+	Hs
		1109982 HDAC1_HUMAN (1-482): 0: 668: 100.00		PF21B_HUMAN (147-668): 1e-38: 152: 29.66
+	Hs
		231139 HDAC1_HUMAN (1-482): 0: 668: 100.00		AIRE_HUMAN (472-538): 1.24e-19: 94.9: 43.06
+	Hs
		231157 HDAC2_HUMAN (1-478): 0: 666: 85.92		AIRE_HUMAN (472-538): 1.24e-19: 94.9: 43.06
+	Hs
		1110005 HDAC1_HUMAN (1-482): 0: 668: 100.00		PHF12_HUMAN (462-541): 2e-13: 76: 31.71
+	Mm
		148718 HDAC1_MOUSE (1-482): 0: 672: 99.38		NSD2_MOUSE (423-540): 5.17e-09: 61.9: 20.00
+	Hs
		355519 HDAC1_HUMAN (1-482): 0: 668: 100.00		NSD2_HUMAN (423-540): 6.19e-09: 61.5: 20.00
+	Hs
		355572 HDAC2_HUMAN (1-478): 0: 666: 85.92		NSD2_HUMAN (423-540): 6.19e-09: 61.5: 20.00