HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KCD18 (Q6PI47)
BTB/POZ domain-containing protein KCTD18
Gene: KCTD18

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.80	0.788

Property	Details
Experiments	35563538, 37495603, 21145461, 34591642
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BTB_2~Cullin
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 426
+	Hs
		1114281 CUL3_HUMAN (1-768): 0: 943: 100.00		BACD3_HUMAN (7-207): 5.15e-51: 176: 21.76
+	Hs
		1113060 CUL3_HUMAN (1-768): 0: 943: 100.00		BACD2_HUMAN (11-207): 1.37e-48: 169: 25.94
+	Hs
		1113860 CUL3_HUMAN (1-768): 0: 943: 100.00		BACD1_HUMAN (11-207): 7.98e-47: 165: 23.11
+	Mm
		1296400 CUL3_MOUSE (1-768): 0: 941: 99.48		BACD1_MOUSE (11-207): 2.06e-47: 167: 23.59
+	Hs
		1113494 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD1_HUMAN (2-193): 1.73e-45: 159: 19.90
+	Hs
		1114460 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD5_HUMAN (5-156): 1.12e-44: 157: 23.72
+	Hs
		1113115 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD2_HUMAN (8-156): 6.1e-42: 150: 25.97
+	Hs
		1113692 CUL3_HUMAN (1-768): 0: 943: 100.00		KCD17_HUMAN (12-156): 6.38e-41: 149: 24.32
+	Hs
		1113259 CUL3_HUMAN (1-768): 0: 943: 100.00		KCD21_HUMAN (10-116): 2.96e-41: 148: 37.04
+	Hs
		1113774 CUL3_HUMAN (1-768): 0: 943: 100.00		SHKB1_HUMAN (2-113): 1.1e-35: 141: 28.57
+	Hs
		1114037 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD7_HUMAN (7-168): 4.98e-38: 141: 24.69
+	Hs
		1113725 CUL3_HUMAN (1-768): 0: 943: 100.00		KCTD6_HUMAN (10-159): 1.78e-37: 137: 28.76
+	Hs
		1113946 CUL3_HUMAN (1-768): 0: 943: 100.00		KCD12_HUMAN (5-102): 2.26e-35: 134: 37.62
+	Dm
		1304397 Q8IP45_DROME (17-768): 0: 857: 69.08		Q9W579_DROME (11-158): 9.86e-42: 148: 19.87
+	Ce
		1019184 CUL3_CAEEL (4-768): 0: 787: 48.08		P91563_CAEEL (10-220): 2.64e-46: 161: 18.83
+	Ce
		1164804 CUL3_CAEEL (4-768): 0: 787: 48.08		Q18986_CAEEL (9-207): 3.09e-43: 153: 22.28
+	Ce
		1164803 CUL3_CAEEL (4-768): 0: 787: 48.08		Q18776_CAEEL (8-172): 3.62e-41: 148: 21.26
+	Hs
		1115352 CUL4B_HUMAN (5-768): 0: 796: 36.77		KCD12_HUMAN (5-102): 2.26e-35: 134: 37.62
+	Ce
		195624 CUL3_CAEEL (4-768): 0: 787: 48.08		O16612_CAEEL (10-174): 4.16e-39: 141: 18.97
+	Ce
		115045 CUL3_CAEEL (4-768): 0: 787: 48.08		H2KY83_CAEEL (10-179): 1.41e-38: 139: 18.18