Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3
Interactor 2: KLH12 (Q53G59)
Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)
Gene: KLHL12
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 1.00 | 0.989 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 27716508, 29999490, 30190310, 18303015, 35120648, 36652337, 37495603, 25416956, 32296183, 34878901, 35563538, 37788672, 16547521, 17543862, 21145461, 19295130, unassigned1304, 34591642 |
| Identification Methods | affinity chromatography technology, two hybrid, pull down, two hybrid prey pooling approach, two hybrid array, validated two hybrid, tandem affinity purification, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | BACK~Cullin, BTB~Cullin |
| Common GO terms | GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006513 - protein monoubiquitination GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport GO:0016055 - Wnt signaling pathway and 3 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
