HitPredict

Interactor 1: CIP4 (Q15642)
Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10)
Gene: TRIP10

Interactor 2: RHG17 (Q68EM7)
Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)
Gene: ARHGAP17

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.915

Property	Details
Experiments	11431473, 25416956, 32296183, unassigned1304
Identification Methods	pull down, two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RhoGAP~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 601 Hs			1 881
+	Hs
		1229254 FNBP1_HUMAN (1-601): 8.28e-102: 323: 49.35		RHG17_HUMAN (1-881): 8.8e-143: 446: 100.00
+	Hs
		1150860 CIP4_HUMAN (1-601): 9.12e-110: 343: 100.00		RHG44_HUMAN (1-756): 4.94e-106: 348: 45.93
+	Hs
		1165232 FBP1L_HUMAN (1-601): 1.3e-107: 337: 51.40		RHG44_HUMAN (1-756): 4.94e-106: 348: 45.93
+	Hs
		1150901 CIP4_HUMAN (1-601): 9.12e-110: 343: 100.00		3BP1_HUMAN (1-651): 2.57e-79: 273: 36.05
+	Hs
		1150861 CIP4_HUMAN (1-601): 9.12e-110: 343: 100.00		Q1RLN5_HUMAN (53-430): 1.16e-65: 237: 18.02
+	Hs
		1150873 CIP4_HUMAN (1-601): 9.12e-110: 343: 100.00		RHG12_HUMAN (53-430): 9.79e-65: 235: 18.02
+	Dm
		118395 M9NE16_DROME (1-600): 2.31e-86: 282: 31.85		RG92B_DROME (1-642): 2.05e-75: 263: 25.76
+	Hs
		212744 SRGP3_HUMAN (4-539): 4.2e-63: 227: 13.04		SRGP3_HUMAN (13-738): 7.28e-82: 287: 15.65
+	Hs
		212750 SRGP3_HUMAN (4-539): 4.2e-63: 227: 13.04		SRGP2_HUMAN (13-833): 1.93e-70: 254: 14.89
+	Hs
		269575 SRGP1_HUMAN (4-539): 2.23e-61: 222: 13.04		SRGP2_HUMAN (13-833): 1.93e-70: 254: 14.89
+	Hs
		212777 SRGP3_HUMAN (4-539): 4.2e-63: 227: 13.04		RHG24_HUMAN (181-631): 3.51e-68: 243: 19.87
+	Hs
		269487 SRGP2_HUMAN (4-539): 1.35e-56: 208: 13.84		SRGP2_HUMAN (13-833): 1.93e-70: 254: 14.89
+	Hs
		597895 FER_HUMAN (1-489): 8.98e-56: 203: 15.32		RHG21_HUMAN (10-685): 2.4e-70: 256: 16.32
+	Hs
		1462295 PACN2_HUMAN (142-600): 8.59e-21: 97.6: 9.59		3BP1_HUMAN (1-651): 2.57e-79: 273: 36.05
+	Hs
		269501 SRG2C_HUMAN (6-285): 5.03e-20: 95.4: 15.84		SRGP2_HUMAN (13-833): 1.93e-70: 254: 14.89
+	Hs
		1061252 SRGP1_HUMAN (4-539): 2.23e-61: 222: 13.04		RHG01_HUMAN (250-412): 3.21e-19: 93.6: 32.73
+	Hs
		597904 FER_HUMAN (1-489): 8.98e-56: 203: 15.32		RHG23_HUMAN (241-445): 1.43e-16: 87: 28.23
+	Hs
		456088 FES_HUMAN (1-286): 2.73e-25: 113: 20.76		BCR_HUMAN (250-408): 2.37e-16: 86.3: 33.54