HitPredict

Interactor 1: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Interactor 2: MIRO2 (Q8IXI1)
Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2)
Gene: RHOT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.578

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LRR_8~Ras, PK_Tyr_Ser-Thr~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 839 Hs			1 618
+	Hs
		412228 NTRK1_HUMAN (16-839): 7.91e-171: 515: 47.95		MIRO2_HUMAN (1-618): 0: 795: 100.00
+	Hs
		650285 FGFR3_HUMAN (140-838): 2.9e-166: 504: 23.59		MIRO2_HUMAN (1-618): 0: 795: 100.00
+	Hs
		412229 NTRK1_HUMAN (16-839): 7.91e-171: 515: 47.95		MIRO1_HUMAN (1-618): 0: 764: 59.65
+	Hs
		411698 NTRK1_HUMAN (16-839): 7.91e-171: 515: 47.95		RB11A_HUMAN (5-202): 4.27e-72: 232: 19.00
+	Hs
		541423 FGFR1_HUMAN (204-838): 7.83e-164: 498: 24.47		RAB1A_HUMAN (5-172): 9.26e-73: 234: 20.59
+	Hs
		541510 FGFR1_HUMAN (204-838): 7.83e-164: 498: 24.47		RB11B_HUMAN (5-218): 1.99e-72: 233: 20.83
+	Hs
		541421 FGFR1_HUMAN (204-838): 7.83e-164: 498: 24.47		RAB8A_HUMAN (5-187): 4.8e-71: 229: 17.30
+	Hs
		580998 ROR2_HUMAN (522-828): 2.98e-67: 243: 41.56		RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69
+	Hs
		953400 ROR2_HUMAN (522-828): 2.98e-67: 243: 41.56		RAC3_HUMAN (3-168): 9.64e-79: 249: 27.22
+	Hs
		955071 ROR2_HUMAN (522-828): 2.98e-67: 243: 41.56		CDC42_HUMAN (3-172): 5.7e-77: 244: 25.54
+	Hs
		988294 ROR2_HUMAN (522-828): 2.98e-67: 243: 41.56		RAC1_HUMAN (3-181): 3.96e-74: 237: 26.43
+	Hs
		955936 DDR2_HUMAN (527-824): 2.06e-70: 250: 43.30		RAB8A_HUMAN (5-187): 4.8e-71: 229: 17.30
+	Hs
		976213 ROR2_HUMAN (522-828): 2.98e-67: 243: 41.56		RB11A_HUMAN (5-202): 4.27e-72: 232: 19.00
+	Hs
		978040 DDR2_HUMAN (527-824): 2.06e-70: 250: 43.30		RHOB_HUMAN (6-168): 4.59e-13: 70.1: 29.38
+	Hs
		466280 DDR2_HUMAN (527-824): 2.06e-70: 250: 43.30		RHOC_HUMAN (6-168): 3.88e-11: 64.3: 28.25
+	Hs
		977946 ROR2_HUMAN (522-828): 2.98e-67: 243: 41.56		RHOB_HUMAN (6-168): 4.59e-13: 70.1: 29.38
+	Hs
		961965 ROR2_HUMAN (522-828): 2.98e-67: 243: 41.56		RHOA_HUMAN (6-168): 1.75e-11: 65.5: 28.25
+	Hs
		466209 ROR2_HUMAN (522-828): 2.98e-67: 243: 41.56		RHOC_HUMAN (6-168): 3.88e-11: 64.3: 28.25
+	Hs
		126555 ROR2_HUMAN (522-828): 2.98e-67: 243: 41.56		RHOD_HUMAN (3-167): 1.27e-10: 63.2: 28.89
+	Hs
		601245 ROR2_HUMAN (522-828): 2.98e-67: 243: 41.56		RHOQ_HUMAN (5-169): 2.03e-10: 62.8: 26.26