HitPredict

Interactor 1: H31T (Q16695)
Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4)
Gene: H3-4

Interactor 2: NSD3 (Q9BZ95)
Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)
Gene: NSD3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.710

Property	Details
Experiments	23269674
Identification Methods	pull down, x-ray crystallography
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	AWS~Histone, Histone~PWWP, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Hs			1 1437
+	Hs
		998773 H31_HUMAN (1-136): 3.36e-62: 188: 97.06		NSD3_HUMAN (1-1437): 0: 1168: 100.00
+	Hs
		355489 H31_HUMAN (1-136): 3.36e-62: 188: 97.06		NSD2_HUMAN (138-1414): 0: 826: 45.25
+	Hs
		355534 H31T_HUMAN (1-136): 1.34e-61: 187: 100.00		NSD2_HUMAN (138-1414): 0: 826: 45.25
+	Hs
		998807 H31_HUMAN (1-136): 3.36e-62: 188: 97.06		SUV92_HUMAN (898-1285): 1.24e-78: 268: 23.36
+	Hs
		913298 H31_HUMAN (1-136): 3.36e-62: 188: 97.06		MSH6_HUMAN (233-594): 1.72e-71: 266: 18.55
+	Hs
		216410 H31_HUMAN (1-136): 3.36e-62: 188: 97.06		SUV91_HUMAN (904-1284): 3.2e-75: 258: 22.84
+	Hs
		998846 H31_HUMAN (1-136): 3.36e-62: 188: 97.06		ASH1L_HUMAN (1013-1314): 6.08e-63: 240: 30.89
+	Hs
		998359 H31_HUMAN (1-136): 3.36e-62: 188: 97.06		EZH2_HUMAN (999-1270): 7.8e-63: 231: 21.95
+	Hs
		1155419 H31T_HUMAN (1-136): 1.34e-61: 187: 100.00		EZH2_HUMAN (999-1270): 7.8e-63: 231: 21.95
+	Hs
		998772 H31_HUMAN (1-136): 3.36e-62: 188: 97.06		SETD2_HUMAN (1047-1322): 4.6e-60: 230: 34.04
+	Hs
		1162033 H31T_HUMAN (1-136): 1.34e-61: 187: 100.00		SETD2_HUMAN (1047-1322): 4.6e-60: 230: 34.04
+	Hs
		998234 H31_HUMAN (1-136): 3.36e-62: 188: 97.06		KMT2A_HUMAN (1131-1285): 3.23e-40: 166: 30.13
+	Hs
		998942 H31_HUMAN (1-136): 3.36e-62: 188: 97.06		KMT2B_HUMAN (1131-1285): 2.72e-40: 166: 31.41
+	Hs
		1041540 H31T_HUMAN (1-136): 1.34e-61: 187: 100.00		KMT2A_HUMAN (1131-1285): 3.23e-40: 166: 30.13
+	Mm
		147453 H33_MOUSE (1-136): 1.86e-61: 186: 93.38		KMT2B_MOUSE (1131-1285): 2.72e-40: 166: 31.41
+	Hs
		998694 H31_HUMAN (1-136): 3.36e-62: 188: 97.06		NSD1_HUMAN (91-724): 8.77e-25: 115: 14.90
+	Hs
		1162005 H31T_HUMAN (1-136): 1.34e-61: 187: 100.00		NSD1_HUMAN (91-724): 8.77e-25: 115: 14.90
+	Hs
		998565 H31_HUMAN (1-136): 3.36e-62: 188: 97.06		KMT2C_HUMAN (1274-1411): 3.66e-14: 80.6: 14.38
+	Hs
		1161950 H31T_HUMAN (1-136): 1.34e-61: 187: 100.00		KMT2C_HUMAN (1274-1411): 3.66e-14: 80.6: 14.38
+	Mm
		107469 H33_MOUSE (1-136): 1.86e-61: 186: 93.38		F8WI37_MOUSE (1274-1411): 9.54e-14: 79.1: 14.38