HitPredict

Interactor 1: NANOG (Q80Z64)
Homeobox protein NANOG (ES cell-associated protein 4) (Early embryo specific expression NK-type homeobox protein) (Homeobox transcription factor Nanog)
Gene: NANOG

Interactor 2: NSD2 (Q8BVE8)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Wolf-Hirschhorn syndrome candidate 1 protein homolog)
Gene: NSD2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.53	0.60	0.565

Property	Details
Experiments	19483677
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0043565 - sequence-specific DNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 305 Mm			1 1365
+	Mm
		788275 NKX25_MOUSE (13-216): 2.84e-33: 126: 22.41		NSD2_MOUSE (1-1365): 0: 1014: 100.00
+	Mm
		1194729 NANOG_MOUSE (1-305): 9.78e-60: 194: 100.00		EHMT2_MOUSE (984-1199): 1.43e-57: 220: 26.42
+	Mm
		1142282 NANOG_MOUSE (1-305): 9.78e-60: 194: 100.00		EZH2_MOUSE (921-1188): 8.08e-55: 207: 22.78
+	Mm
		139070 NANOG_MOUSE (1-305): 9.78e-60: 194: 100.00		KMT2B_MOUSE (1049-1203): 9.5e-43: 174: 32.05
+	Hs
		679157 TLX1_HUMAN (29-215): 3.58e-34: 128: 22.80		EHMT2_HUMAN (892-1216): 8.25e-55: 212: 20.11
+	Hs
		679173 TLX1_HUMAN (29-215): 3.58e-34: 128: 22.80		EHMT1_HUMAN (906-1219): 9.69e-55: 212: 21.41
+	Hs
		839806 LHX2_HUMAN (8-232): 1.48e-30: 120: 15.49		EHMT2_HUMAN (892-1216): 8.25e-55: 212: 20.11
+	Hs
		839827 LHX2_HUMAN (8-232): 1.48e-30: 120: 15.49		EHMT1_HUMAN (906-1219): 9.69e-55: 212: 21.41
+	Hs
		641528 PAX6_HUMAN (37-288): 5.3e-30: 119: 15.69		EHMT2_HUMAN (892-1216): 8.25e-55: 212: 20.11
+	Hs
		641566 PAX6_HUMAN (37-288): 5.3e-30: 119: 15.69		EHMT1_HUMAN (906-1219): 9.69e-55: 212: 21.41
+	Mm
		101829 NANOG_MOUSE (1-305): 9.78e-60: 194: 100.00		F8WI37_MOUSE (1195-1361): 1.07e-09: 65.7: 15.22
+	Mm
		1194614 NANOG_MOUSE (1-305): 9.78e-60: 194: 100.00		KMT2C_MOUSE (1195-1361): 1.08e-09: 65.7: 15.22
+	Hs
		152588 PAX7_HUMAN (79-299): 1.61e-33: 130: 16.81		KMT2D_HUMAN (84-666): 1.38e-11: 71.9: 10.34
+	Hs
		152596 TLX1_HUMAN (29-215): 3.58e-34: 128: 22.80		KMT2D_HUMAN (84-666): 1.38e-11: 71.9: 10.34
+	Hs
		620175 PAX7_HUMAN (79-299): 1.61e-33: 130: 16.81		KMT2C_HUMAN (1195-1361): 8.77e-10: 66.1: 14.67
+	Hs
		679137 TLX1_HUMAN (29-215): 3.58e-34: 128: 22.80		KMT2C_HUMAN (1195-1361): 8.77e-10: 66.1: 14.67
+	Hs
		152615 LHX2_HUMAN (8-232): 1.48e-30: 120: 15.49		KMT2D_HUMAN (84-666): 1.38e-11: 71.9: 10.34
+	Hs
		152592 PAX6_HUMAN (37-288): 5.3e-30: 119: 15.69		KMT2D_HUMAN (84-666): 1.38e-11: 71.9: 10.34
+	Hs
		839785 LHX2_HUMAN (8-232): 1.48e-30: 120: 15.49		KMT2C_HUMAN (1195-1361): 8.77e-10: 66.1: 14.67
+	Hs
		641482 PAX6_HUMAN (37-288): 5.3e-30: 119: 15.69		KMT2C_HUMAN (1195-1361): 8.77e-10: 66.1: 14.67