HitPredict

Interactor 1: RASK (P32883)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: Kras

Interactor 2: PK3CA (P42337)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)
Gene: Pik3ca

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23706742
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~Ras, PI3K_rbd~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0030036 - actin cytoskeleton organization GO:0043524 - negative regulation of neuron apoptotic process GO:0048009 - insulin-like growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Mm			1 1068
+	Hs
		349170 RASH_HUMAN (1-188): 3.11e-87: 256: 86.77		PK3CA_HUMAN (1-1068): 0: 1315: 98.69
+	Mm
		787349 RASH_MOUSE (1-188): 3.11e-87: 256: 86.77		PK3CA_MOUSE (1-1068): 0: 1314: 100.00
+	Mm
		440301 RASN_MOUSE (1-189): 5.14e-87: 255: 86.77		PK3CA_MOUSE (1-1068): 0: 1314: 100.00
+	Hs
		348554 RASN_HUMAN (1-189): 3.17e-86: 253: 86.24		PK3CA_HUMAN (1-1068): 0: 1315: 98.69
+	Hs
		349946 RASK_HUMAN (1-189): 6.74e-78: 232: 98.94		PK3CA_HUMAN (1-1068): 0: 1315: 98.69
+	Hs
		126186 RASH_HUMAN (1-188): 3.11e-87: 256: 86.77		PK3CD_HUMAN (1-1065): 0: 1167: 39.72
+	Mm
		193571 RASH_MOUSE (1-188): 3.11e-87: 256: 86.77		PK3CD_MOUSE (1-1065): 0: 1163: 39.72
+	Mm
		193564 RASN_MOUSE (1-189): 5.14e-87: 255: 86.77		PK3CD_MOUSE (1-1065): 0: 1163: 39.72
+	Mm
		193569 RASK_MOUSE (1-189): 2.66e-78: 233: 100.00		PK3CD_MOUSE (1-1065): 0: 1163: 39.72
+	Mm
		1142560 RASH_MOUSE (1-188): 3.11e-87: 256: 86.77		PK3CB_MOUSE (1-1065): 0: 1070: 38.57
+	Hs
		349947 RASK_HUMAN (1-189): 6.74e-78: 232: 98.94		PK3CB_HUMAN (1-1065): 0: 1050: 39.40
+	Dm
		442990 RAS1_DROME (1-165): 2.98e-88: 258: 86.06		P91634_DROME (7-1065): 0: 954: 34.49
+	Mm
		1142568 RASH_MOUSE (1-188): 3.11e-87: 256: 86.77		PK3CG_MOUSE (1-1062): 0: 923: 32.29
+	Mm
		440303 RASN_MOUSE (1-189): 5.14e-87: 255: 86.77		PK3CG_MOUSE (1-1062): 0: 923: 32.29
+	Mm
		699626 RASK_MOUSE (1-189): 2.66e-78: 233: 100.00		PK3CG_MOUSE (1-1062): 0: 923: 32.29
+	Hs
		349183 RASH_HUMAN (1-188): 3.11e-87: 256: 86.77		PK3CG_HUMAN (1-1062): 0: 891: 31.81
+	Hs
		348567 RASN_HUMAN (1-189): 3.17e-86: 253: 86.24		PK3CG_HUMAN (1-1062): 0: 891: 31.81
+	Hs
		349368 RASH_HUMAN (1-188): 3.11e-87: 256: 86.77		Q4LE69_HUMAN (562-1066): 1.48e-139: 466: 25.23
+	Hs
		348701 RASN_HUMAN (1-189): 3.17e-86: 253: 86.24		Q4LE69_HUMAN (562-1066): 1.48e-139: 466: 25.23
+	Hs
		1070222 RAB35_HUMAN (4-187): 2.06e-83: 246: 31.28		Q4LE69_HUMAN (562-1066): 1.48e-139: 466: 25.23