HitPredict

Interactor 1: PYDC2 (Q56P42)
Pyrin domain-containing protein 2 (Pyrin-only protein 2) (cellular POP2) (cPOP2)
Gene: PYDC2

Interactor 2: NALP2 (Q9NX02)
NACHT, LRR and PYD domains-containing protein 2 (Nucleotide-binding site protein 1) (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2)
Gene: NLRP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.683

Property	Details
Experiments	17178784
Identification Methods	pull down, anti tag coimmunoprecipitation, two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PYRIN~PYRIN
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006954 - inflammatory response GO:0045087 - innate immune response GO:1901223 - negative regulation of non-canonical NF-kappaB signal transduction
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 97 Hs			1 1062
+	Hs
		1292003 NAL10_HUMAN (1-93): 6.95e-25: 98.5: 19.36		NAL10_HUMAN (1-652): 5.75e-148: 458: 23.33
+	Mm
		1341590 NLRP3_MOUSE (11-91): 1.68e-27: 106: 24.69		NLRP3_MOUSE (789-1055): 5.57e-47: 185: 34.83
+	Hs
		1399385 NLRP3_HUMAN (3-91): 4.08e-27: 105: 22.47		NLRP3_HUMAN (790-1054): 1.25e-46: 184: 34.34
+	Hs
		194785 MEFV_HUMAN (1-93): 2.08e-24: 97.4: 21.51		NLRP3_HUMAN (790-1054): 1.25e-46: 184: 34.34
+	Hs
		562636 NLRP3_HUMAN (3-91): 4.08e-27: 105: 22.47		RINI_HUMAN (756-1056): 7.29e-46: 174: 30.57
+	Hs
		1292001 NAL14_HUMAN (7-91): 4.73e-28: 107: 30.59		NAL14_HUMAN (599-984): 3.09e-41: 167: 27.25
+	Hs
		1201301 NALP4_HUMAN (1-91): 2.92e-36: 131: 31.87		PYDC2_HUMAN (1-90): 8.07e-32: 121: 67.78
+	Hs
		947355 PYDC2_HUMAN (1-97): 7.67e-33: 111: 100.00		NAL12_HUMAN (852-1054): 3.87e-32: 137: 36.45
+	Hs
		1398258 NALP4_HUMAN (1-91): 2.92e-36: 131: 31.87		NLRC4_HUMAN (588-959): 4.66e-20: 98.6: 15.12
+	Hs
		947391 NLRP3_HUMAN (3-91): 4.08e-27: 105: 22.47		NALP5_HUMAN (773-1054): 3.19e-26: 118: 22.59
+	Hs
		947395 NALP2_HUMAN (1-91): 1.2e-26: 103: 67.03		NALP5_HUMAN (773-1054): 3.19e-26: 118: 22.59
+	Hs
		1399392 NLRP3_HUMAN (3-91): 4.08e-27: 105: 22.47		NOD2_HUMAN (844-1054): 5.39e-21: 101: 24.65
+	Hs
		1399394 NLRP3_HUMAN (3-91): 4.08e-27: 105: 22.47		NLRC4_HUMAN (588-959): 4.66e-20: 98.6: 15.12
+	Hs
		1201302 PYDC2_HUMAN (1-97): 7.67e-33: 111: 100.00		NLRP1_HUMAN (11-201): 5.53e-14: 79: 10.73
+	Hs
		1360126 NALP2_HUMAN (1-91): 1.2e-26: 103: 67.03		NALP7_HUMAN (842-1054): 1.44e-14: 80.5: 23.36
+	Hs
		947389 NALP5_HUMAN (6-91): 1.24e-24: 97.8: 27.91		NALP7_HUMAN (842-1054): 1.44e-14: 80.5: 23.36