HitPredict

Interactor 1: NAL12 (P59046)
NACHT, LRR and PYD domains-containing protein 12 (Monarch-1) (PYRIN-containing APAF1-like protein 7) (Regulated by nitric oxide)
Gene: NLRP12

Interactor 2: PYDC2 (Q56P42)
Pyrin domain-containing protein 2 (Pyrin-only protein 2) (cellular POP2) (cPOP2)
Gene: PYDC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	17178784
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PYRIN~PYRIN
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0050728 - negative regulation of inflammatory response GO:1901223 - negative regulation of non-canonical NF-kappaB signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1061 Hs			1 97
+	Hs
		1360126 NALP7_HUMAN (13-1001): 0: 578: 30.97		NALP2_HUMAN (1-91): 1.2e-26: 103: 67.03
+	Hs
		947389 NALP7_HUMAN (13-1001): 0: 578: 30.97		NALP5_HUMAN (6-91): 1.24e-24: 97.8: 27.91
+	Hs
		1360106 NALP7_HUMAN (13-1001): 0: 578: 30.97		NALP7_HUMAN (3-91): 8.29e-24: 95.5: 41.57
+	Hs
		1292003 NAL10_HUMAN (13-596): 2.12e-136: 428: 35.65		NAL10_HUMAN (1-93): 6.95e-25: 98.5: 19.36
+	Hs
		1292009 NAL10_HUMAN (13-596): 2.12e-136: 428: 35.65		ASC_HUMAN (8-89): 2.17e-12: 61.6: 18.29
+	Hs
		1399385 NLRP3_HUMAN (806-1060): 8.34e-45: 178: 45.10		NLRP3_HUMAN (3-91): 4.08e-27: 105: 22.47
+	Mm
		1341590 NLRP3_MOUSE (805-1060): 6.47e-43: 172: 45.70		NLRP3_MOUSE (11-91): 1.68e-27: 106: 24.69
+	Hs
		947391 NLRP3_HUMAN (806-1060): 8.34e-45: 178: 45.10		NALP5_HUMAN (6-91): 1.24e-24: 97.8: 27.91
+	Hs
		194785 NLRP3_HUMAN (806-1060): 8.34e-45: 178: 45.10		MEFV_HUMAN (1-93): 2.08e-24: 97.4: 21.51
+	Hs
		1201301 NALP4_HUMAN (594-947): 2.88e-36: 150: 28.49		PYDC2_HUMAN (1-97): 7.67e-33: 111: 100.00
+	Mm
		1341594 NLRP3_MOUSE (805-1060): 6.47e-43: 172: 45.70		ASC_MOUSE (8-89): 4.36e-21: 84.3: 21.95
+	Hs
		562636 RINI_HUMAN (858-1060): 6.42e-36: 144: 35.97		NLRP3_HUMAN (3-91): 4.08e-27: 105: 22.47
+	Hs
		1399406 NLRP3_HUMAN (806-1060): 8.34e-45: 178: 45.10		ASC_HUMAN (8-89): 2.17e-12: 61.6: 18.29
+	Hs
		947395 NALP5_HUMAN (803-1061): 1.25e-25: 116: 26.62		NALP2_HUMAN (1-91): 1.2e-26: 103: 67.03
+	Hs
		1292001 NAL14_HUMAN (797-1061): 9.7e-24: 110: 30.53		NAL14_HUMAN (7-91): 4.73e-28: 107: 30.59
+	Hs
		1273881 NLRC3_HUMAN (773-1060): 1.51e-34: 145: 23.88		ASC_HUMAN (8-89): 2.17e-12: 61.6: 18.29
+	Hs
		166114 RINI_HUMAN (858-1060): 6.42e-36: 144: 35.97		AIM2_HUMAN (3-91): 4.47e-09: 53.5: 21.35
+	Hs
		194792 NALP2_HUMAN (873-1061): 4.43e-15: 82.4: 32.28		MEFV_HUMAN (1-93): 2.08e-24: 97.4: 21.51