HitPredict

Interactor 1: FBW1B (Q5SRY7)
F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)
Gene: Fbxw11

Interactor 2: SKP1 (Q9WTX5)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1)
Gene: SKP1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11896578
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	F-box-like~Skp1, Skp1~WD40
Common GO terms	GO:0005829 - cytosol GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:1990756 - ubiquitin-like ligase-substrate adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 542 Mm			1 163
+	Hs
		992384 FBW1B_HUMAN (1-542): 1.02e-172: 500: 99.63		SKP1_HUMAN (1-163): 5.93e-91: 263: 99.39
+	Hs
		992399 FBW1A_HUMAN (31-542): 2.47e-150: 445: 85.02		SKP1_HUMAN (1-163): 5.93e-91: 263: 99.39
+	Mm
		1190510 FBW1A_MOUSE (38-542): 1.51e-149: 443: 85.49		SKP1_MOUSE (1-163): 3.58e-91: 263: 100.00
+	Hs
		261394 TBL1X_HUMAN (28-392): 5.44e-61: 212: 14.10		SKP1_HUMAN (1-163): 5.93e-91: 263: 99.39
+	Mm
		1353852 FBXW7_MOUSE (349-536): 1.73e-50: 186: 30.91		SKP1_MOUSE (1-163): 3.58e-91: 263: 100.00
+	Hs
		992290 FBXW7_HUMAN (349-536): 3.62e-50: 185: 30.91		SKP1_HUMAN (1-163): 5.93e-91: 263: 99.39
+	Xl
		1259301 TRCB_XENLA (346-538): 7.98e-46: 170: 31.44		SKP1_XENLA (1-163): 5.93e-91: 263: 99.39
+	Dm
		305542 FBXW7_DROME (349-540): 4.45e-51: 190: 30.57		O77430_DROME (1-163): 3.98e-82: 240: 76.07
+	Sp
		1068653 POF11_SCHPO (63-393): 2.08e-57: 201: 14.20		SKP1_SCHPO (1-163): 1.78e-74: 221: 56.36
+	Dm
		232056 O44382_DROME (346-538): 5.75e-46: 170: 30.41		O77430_DROME (1-163): 3.98e-82: 240: 76.07
+	Dm
		305505 Q9VDE3_DROME (346-538): 8.61e-46: 170: 30.41		O77430_DROME (1-163): 3.98e-82: 240: 76.07
+	Dm
		1267182 Q9VDE3_DROME (346-538): 8.61e-46: 170: 30.41		Q7KJ69_DROME (1-163): 1.73e-76: 226: 67.49
+	Sp
		1017865 POF1_SCHPO (346-541): 5e-46: 172: 27.78		SKP1_SCHPO (1-163): 1.78e-74: 221: 56.36
+	Hs
		992222 TRAF7_HUMAN (353-522): 6.18e-29: 123: 27.17		SKP1_HUMAN (1-163): 5.93e-91: 263: 99.39
+	Sc
		809273 MET30_YEAST (346-535): 4.95e-47: 175: 26.04		SKP1_YEAST (4-163): 2.13e-66: 202: 42.63
+	Sp
		1017871 POP1_SCHPO (323-542): 2.85e-38: 151: 21.61		SKP1_SCHPO (1-163): 1.78e-74: 221: 56.36
+	Hs
		992390 FBXW2_HUMAN (357-517): 8.28e-25: 109: 27.59		SKP1_HUMAN (1-163): 5.93e-91: 263: 99.39
+	Ce
		111663 LIN23_CAEEL (348-538): 7.99e-44: 166: 31.94		G5EDD8_CAEEL (4-162): 4.76e-67: 203: 60.25
+	Dm
		1471477 Q9VDE3_DROME (346-538): 8.61e-46: 170: 30.41		Q9VWC4_DROME (2-153): 2.3e-65: 198: 56.86
+	Ce
		111145 SEL10_CAEEL (107-301): 4.44e-22: 101: 10.68		SKR1_CAEEL (4-162): 1.31e-80: 237: 70.81