HitPredict

Interactor 1: Q9VDE3 (Q9VDE3)
LD08669p (Slimb) (Supernumerary limbs, isoform A) (Supernumerary limbs, isoform C)
Gene: slmb

Interactor 2: Q9VWC4 (Q9VWC4)
RT03845p (SKP1-related C) (SKPC)
Gene: SkpC

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	F-box-like~Skp1, Skp1~WD40
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 510 Dm			1 158
+	Hs
		992399 FBW1A_HUMAN (316-510): 2.22e-50: 183: 29.59		SKP1_HUMAN (4-157): 2.35e-73: 218: 52.26
+	Mm
		1190510 FBW1A_MOUSE (316-510): 1.85e-49: 181: 30.10		SKP1_MOUSE (4-157): 1.36e-73: 219: 52.90
+	Mm
		1210439 FBW1B_MOUSE (322-510): 5.65e-49: 178: 31.22		SKP1_MOUSE (4-157): 1.36e-73: 219: 52.90
+	Xl
		1259301 TRCB_XENLA (316-510): 1.5e-49: 179: 30.10		SKP1_XENLA (4-157): 2.35e-73: 218: 52.26
+	Hs
		992384 FBW1B_HUMAN (322-510): 7.98e-49: 178: 30.69		SKP1_HUMAN (4-157): 2.35e-73: 218: 52.26
+	Dm
		232056 O44382_DROME (316-510): 1.14e-49: 179: 29.59		O77430_DROME (4-157): 1.49e-71: 213: 57.14
+	Hs
		261394 TBL1X_HUMAN (285-509): 2.62e-47: 174: 17.55		SKP1_HUMAN (4-157): 2.35e-73: 218: 52.26
+	Dm
		305505 Q9VDE3_DROME (316-510): 1.58e-49: 179: 29.59		O77430_DROME (4-157): 1.49e-71: 213: 57.14
+	Dm
		1267182 Q9VDE3_DROME (316-510): 1.58e-49: 179: 29.59		Q7KJ69_DROME (4-157): 1.77e-64: 196: 47.40
+	Sp
		1017871 POP1_SCHPO (105-398): 5.63e-46: 173: 19.13		SKP1_SCHPO (5-157): 5.9e-66: 199: 45.46
+	Mm
		1353852 FBXW7_MOUSE (358-510): 2.12e-38: 151: 28.57		SKP1_MOUSE (4-157): 1.36e-73: 219: 52.90
+	Hs
		992290 FBXW7_HUMAN (358-510): 4.25e-38: 150: 28.57		SKP1_HUMAN (4-157): 2.35e-73: 218: 52.26
+	Dm
		305542 FBXW7_DROME (358-510): 8.96e-39: 153: 28.57		O77430_DROME (4-157): 1.49e-71: 213: 57.14
+	Ce
		111663 LIN23_CAEEL (318-510): 3.06e-48: 178: 31.61		G5EDD8_CAEEL (2-157): 2.3e-59: 183: 38.99
+	Sp
		1068653 POF11_SCHPO (299-510): 9.93e-43: 160: 25.00		SKP1_SCHPO (5-157): 5.9e-66: 199: 45.46
+	Ce
		111145 SEL10_CAEEL (368-509): 3.48e-32: 131: 28.28		SKR1_CAEEL (2-157): 2.31e-71: 213: 42.14
+	Sp
		1017865 POF1_SCHPO (359-509): 4.99e-35: 140: 29.61		SKP1_SCHPO (5-157): 5.9e-66: 199: 45.46
+	Hs
		992212 FBW10_HUMAN (337-490): 1.7e-27: 118: 23.00		SKP1_HUMAN (4-157): 2.35e-73: 218: 52.26
+	Hs
		992390 FBXW2_HUMAN (366-502): 2.83e-24: 107: 27.34		SKP1_HUMAN (4-157): 2.35e-73: 218: 52.26
+	Sc
		809273 MET30_YEAST (359-509): 5.24e-34: 137: 26.32		SKP1_YEAST (1-156): 4.27e-60: 186: 31.55