HitPredict

Interactor 1: SKP1 (Q71U00)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1)
Gene: SKP1

Interactor 2: TRCB (Q91854)
Beta-TrCP (Beta-transducin repeat-containing protein)
Gene: fbxw1

Species: Xenopus laevis

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	10339577
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	F-box-like~Skp1, Skp1~WD40
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 163 Xl			1 518
+	Mm
		1353852 SKP1_MOUSE (1-163): 8.92e-88: 255: 99.39		FBXW7_MOUSE (34-416): 2.58e-72: 245: 19.49
+	Sp
		1068653 SKP1_SCHPO (1-163): 6.57e-73: 217: 56.36		POF11_SCHPO (19-514): 8.4e-88: 280: 26.74
+	Hs
		992290 SKP1_HUMAN (1-163): 1.63e-87: 254: 100.00		FBXW7_HUMAN (34-416): 1.52e-71: 243: 19.49
+	Hs
		261394 SKP1_HUMAN (1-163): 1.63e-87: 254: 100.00		TBL1X_HUMAN (3-384): 3.67e-54: 193: 14.68
+	Dm
		232056 O77430_DROME (1-163): 1.01e-79: 235: 76.69		O44382_DROME (312-517): 1.01e-53: 190: 32.54
+	Dm
		305505 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9VDE3_DROME (312-517): 1.35e-53: 190: 32.54
+	Dm
		305542 O77430_DROME (1-163): 1.01e-79: 235: 76.69		FBXW7_DROME (341-516): 2.7e-48: 181: 30.77
+	Dm
		1267182 Q7KJ69_DROME (1-163): 1.93e-74: 221: 67.49		Q9VDE3_DROME (312-517): 1.35e-53: 190: 32.54
+	Sp
		1017871 SKP1_SCHPO (1-163): 6.57e-73: 217: 56.36		POP1_SCHPO (121-451): 6.52e-48: 179: 19.33
+	Ce
		111663 G5EDD8_CAEEL (4-162): 1.85e-65: 199: 60.25		LIN23_CAEEL (312-517): 1.16e-53: 193: 30.62
+	Hs
		992222 SKP1_HUMAN (1-163): 1.63e-87: 254: 100.00		TRAF7_HUMAN (345-517): 5.39e-30: 126: 27.27
+	Sp
		153337 SKP1_SCHPO (1-163): 6.57e-73: 217: 56.36		POP2_SCHPO (128-371): 4.92e-38: 150: 19.03
+	Sc
		460737 SKP1_YEAST (2-163): 5.87e-65: 198: 42.19		CDC4_YEAST (155-451): 2.07e-44: 169: 18.73
+	Sp
		1017865 SKP1_SCHPO (1-163): 6.57e-73: 217: 56.36		POF1_SCHPO (1-360): 3.8e-38: 149: 15.98
+	Hs
		992390 SKP1_HUMAN (1-163): 1.63e-87: 254: 100.00		FBXW2_HUMAN (388-517): 8.13e-25: 108: 25.00
+	Ce
		111145 SKR1_CAEEL (4-162): 2.26e-78: 232: 70.81		SEL10_CAEEL (389-518): 1.72e-27: 118: 31.58
+	Mm
		1210439 SKP1_MOUSE (1-163): 8.92e-88: 255: 99.39		FBW1B_MOUSE (423-517): 1.64e-15: 81.1: 30.53
+	Hs
		992384 SKP1_HUMAN (1-163): 1.63e-87: 254: 100.00		FBW1B_HUMAN (423-517): 2.42e-15: 80.7: 30.53
+	Hs
		992399 SKP1_HUMAN (1-163): 1.63e-87: 254: 100.00		FBW1A_HUMAN (423-517): 4.12e-15: 80: 30.53
+	Mm
		1190510 SKP1_MOUSE (1-163): 8.92e-88: 255: 99.39		FBW1A_MOUSE (423-517): 1.82e-14: 78: 30.53