HitPredict

Interactor 1: O77430 (O77430)
GEO01111p1 (HL01263p) (RH26825p) (SKP1-related A, isoform A) (SKP1-related A, isoform B) (SKP1-related A, isoform C) (SKP1-related A, isoform E) (SKP1-related A, isoform F) (SKP1-related A, isoform G) (SKPA)
Gene: SkpA

Interactor 2: Q9VDE3 (Q9VDE3)
LD08669p (Slimb) (Supernumerary limbs, isoform A) (Supernumerary limbs, isoform C)
Gene: slmb

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.973

The method score is based on:

Property Details
Experiments 25533207, 14605208, 15575970, 23747190, 24068890, 15710747, 22036573, 19084407, 19171756, 38944040
Identification Methods affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid fragment pooling approach
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains F-box-like~Skp1, Skp1~WD40
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0019005 - SCF ubiquitin ligase complex
GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0043066 - negative regulation of apoptotic process
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 162
Dm

1 510
+ Hs
+ Mm
+ Mm
+ Xl
+ Dm
+ Hs
+ Hs
+ Dm
+ Dm
+ Mm
+ Hs
+ Sp
+ Sp
+ Ce
+ Hs
+ Sp
+ Hs
+ Mm
+ Hs
+ Sp

Service provided by Combinatics, Japan

Last updated: 11Aug2025