HitPredict

Interactor 1: RHG17 (Q68EM7)
Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)
Gene: ARHGAP17

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.741

Property	Details
Experiments	28514442, 31980649, 33961781, 19531213, 16678097, unassigned2173, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 881 Hs			1 665
+	Hs
		1229264 RHG17_HUMAN (1-881): 8.8e-143: 446: 100.00		CD2AP_HUMAN (1-664): 1.84e-95: 309: 32.36
+	Hs
		1165236 RHG44_HUMAN (1-756): 4.94e-106: 348: 45.93		SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00
+	Hs
		1279847 SRGP1_HUMAN (13-817): 1.68e-86: 300: 15.13		SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00
+	Hs
		1384313 3BP1_HUMAN (1-651): 2.57e-79: 273: 36.05		SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00
+	Hs
		1165243 RHG44_HUMAN (1-756): 4.94e-106: 348: 45.93		CD2AP_HUMAN (1-664): 1.84e-95: 309: 32.36
+	Hs
		49975 RHG10_HUMAN (2-603): 5.02e-73: 257: 13.97		SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00
+	Hs
		1491252 3BP1_HUMAN (1-651): 2.57e-79: 273: 36.05		CD2AP_HUMAN (1-664): 1.84e-95: 309: 32.36
+	Hs
		987703 RHG17_HUMAN (1-881): 8.8e-143: 446: 100.00		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37
+	Hs
		1229242 RHG17_HUMAN (1-881): 8.8e-143: 446: 100.00		DNMBP_HUMAN (4-581): 5.37e-24: 110: 12.50
+	Hs
		1121963 SRGP1_HUMAN (13-817): 1.68e-86: 300: 15.13		ARHG7_HUMAN (2-595): 6.82e-34: 140: 16.23
+	Hs
		1140174 RHG44_HUMAN (1-756): 4.94e-106: 348: 45.93		ARHG6_HUMAN (213-349): 2.26e-13: 75.5: 23.36
+	Hs
		212764 SRGP3_HUMAN (13-738): 7.28e-82: 287: 15.65		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37
+	Hs
		269561 SRGP2_HUMAN (13-833): 1.93e-70: 254: 14.89		SPD2A_HUMAN (3-650): 8.88e-37: 150: 16.74
+	Hs
		987971 RHG35_HUMAN (79-472): 1.23e-69: 254: 19.90		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37
+	Hs
		987675 Q1RLN5_HUMAN (53-430): 1.16e-65: 237: 18.02		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37
+	Hs
		594020 RHG21_HUMAN (10-685): 2.4e-70: 256: 16.32		NCK1_HUMAN (104-413): 3.74e-26: 112: 16.62
+	Hs
		987756 RHG12_HUMAN (53-430): 9.79e-65: 235: 18.02		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37
+	Hs
		269623 SRGP2_HUMAN (13-833): 1.93e-70: 254: 14.89		ITSN2_HUMAN (214-418): 8.13e-14: 77.4: 15.61
+	Hs
		269586 SRGP2_HUMAN (13-833): 1.93e-70: 254: 14.89		SH3R3_HUMAN (195-534): 4.22e-13: 74.7: 10.57
+	Dm
		1477678 RHGF_DROME (1-711): 1.84e-72: 260: 13.63		Q9VIN1_DROME (98-632): 5.28e-11: 67.8: 12.91