HitPredict

Interactor 1: CCL8 (P80075)
C-C motif chemokine 8 (HC14) (Monocyte chemoattractant protein 2) (Monocyte chemotactic protein 2) (MCP-2) (Small-inducible cytokine A8) [Cleaved into: MCP-2(6-76)]
Gene: CCL8

Interactor 2: ACKR4 (Q9NPB9)
Atypical chemokine receptor 4 (C-C chemokine receptor type 11) (C-C CKR-11) (CC-CKR-11) (CCR-11) (CC chemokine receptor-like 1) (CCRL1) (CCX CKR)
Gene: ACKR4

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	10734104
Identification Methods	biochemical, competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 99 Hs			1 350
+	Hs
		1305163 CCL13_HUMAN (1-98): 3.21e-37: 122: 62.25		ACKR4_HUMAN (1-350): 4.66e-89: 272: 100.00
+	Hs
		849619 CCL13_HUMAN (1-98): 3.21e-37: 122: 62.25		CCR3_HUMAN (7-349): 1.94e-86: 266: 29.23
+	Hs
		561732 CL3L1_HUMAN (1-94): 5.23e-36: 119: 40.43		CCR3_HUMAN (7-349): 1.94e-86: 266: 29.23
+	Hs
		134400 CCL13_HUMAN (1-98): 3.21e-37: 122: 62.25		ACKR2_HUMAN (2-332): 5.17e-81: 253: 32.15
+	Hs
		134356 CCL4_HUMAN (1-93): 9.27e-35: 116: 37.63		ACKR2_HUMAN (2-332): 5.17e-81: 253: 32.15
+	Hs
		134373 CCL8_HUMAN (1-99): 5.16e-35: 116: 100.00		ACKR2_HUMAN (2-332): 5.17e-81: 253: 32.15
+	Mm
		291526 CCL11_MOUSE (1-99): 6.84e-35: 116: 53.54		CXCR3_MOUSE (3-349): 2.46e-79: 248: 28.29
+	Hs
		783833 CCL13_HUMAN (1-98): 3.21e-37: 122: 62.25		CCR2_HUMAN (1-327): 1.37e-72: 231: 29.39
+	Mm
		486358 CCL2_MOUSE (1-99): 9.79e-37: 122: 50.51		CCR2_MOUSE (1-349): 7.53e-71: 227: 28.69
+	Hs
		830629 CCL13_HUMAN (1-98): 3.21e-37: 122: 62.25		CXCR3_HUMAN (2-349): 7.54e-71: 227: 29.63
+	Hs
		849654 CCL13_HUMAN (1-98): 3.21e-37: 122: 62.25		CCR5_HUMAN (12-349): 4.53e-71: 227: 30.23
+	Mm
		500590 CCL3_MOUSE (1-94): 5.02e-35: 116: 38.30		CCR1_MOUSE (10-349): 4.08e-73: 232: 30.64
+	Hs
		783815 CCL8_HUMAN (1-99): 5.16e-35: 116: 100.00		CCR2_HUMAN (1-327): 1.37e-72: 231: 29.39
+	Hs
		561733 CL3L1_HUMAN (1-94): 5.23e-36: 119: 40.43		CCR5_HUMAN (12-349): 4.53e-71: 227: 30.23
+	Hs
		561728 CL3L1_HUMAN (1-94): 5.23e-36: 119: 40.43		CCR1_HUMAN (30-344): 8.33e-71: 226: 30.79
+	Mm
		500591 CCL3_MOUSE (1-94): 5.02e-35: 116: 38.30		CCR3_MOUSE (30-348): 1.44e-71: 228: 31.39
+	Hs
		849647 CCL8_HUMAN (1-99): 5.16e-35: 116: 100.00		CCR5_HUMAN (12-349): 4.53e-71: 227: 30.23
+	Hs
		526560 CCL4_HUMAN (1-93): 9.27e-35: 116: 37.63		CCR1_HUMAN (30-344): 8.33e-71: 226: 30.79
+	Hs
		686635 CCL8_HUMAN (1-99): 5.16e-35: 116: 100.00		CCR1_HUMAN (30-344): 8.33e-71: 226: 30.79
+	Mm
		139696 CCL2_MOUSE (1-99): 9.79e-37: 122: 50.51		ACKR2_MOUSE (22-314): 1.65e-39: 145: 31.37