HitPredict

Interactor 1: CBLC (Q80XL1)
E3 ubiquitin-protein ligase CBL-C (EC 2.3.2.27) (RING-type E3 ubiquitin transferase CBL-C) (SH3-binding protein CBL-3) (SH3-binding protein CBL-C) (Signal transduction protein CBL-C)
Gene: CBLC

Interactor 2: SH2B2 (Q9JID9)
SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)
Gene: SH2B2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	12842890
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 496 Mm			1 621
+	Mm
		651580 CBL_MOUSE (14-480): 0: 690: 45.28		SH2B2_MOUSE (1-621): 0: 538: 100.00
+	Hs
		584532 CBLB_HUMAN (4-468): 0: 686: 42.28		VAV_HUMAN (181-602): 3.83e-67: 236: 11.57
+	Mm
		86323 B9EKI5_MOUSE (4-468): 0: 689: 42.48		VAV2_MOUSE (181-599): 1.8e-59: 215: 12.58
+	Hs
		222074 CBLB_HUMAN (4-468): 0: 686: 42.28		NCK2_HUMAN (163-499): 2.41e-54: 191: 14.89
+	Mm
		431323 CBL_MOUSE (14-480): 0: 690: 45.28		SRC_MOUSE (283-506): 7.65e-50: 183: 14.34
+	Mm
		651564 CBL_MOUSE (14-480): 0: 690: 45.28		NCK1_MOUSE (163-499): 2.54e-50: 180: 14.45
+	Mm
		86325 B9EKI5_MOUSE (4-468): 0: 689: 42.48		NCK1_MOUSE (163-499): 2.54e-50: 180: 14.45
+	Mm
		237074 CBLB_MOUSE (4-468): 0: 690: 42.48		NCK2_MOUSE (163-499): 6.37e-49: 176: 14.61
+	Rn
		93099 D3ZV15_RAT (14-480): 0: 686: 45.28		SHC1_RAT (299-507): 4.02e-48: 177: 20.28
+	Mm
		651513 CBL_MOUSE (14-480): 0: 690: 45.28		SHC1_MOUSE (299-507): 4.66e-45: 170: 20.85
+	Hs
		557275 CBLB_HUMAN (4-468): 0: 686: 42.28		SRC_HUMAN (283-513): 3.51e-41: 159: 15.87
+	Mm
		651535 CBL_MOUSE (14-480): 0: 690: 45.28		PLCG1_MOUSE (393-616): 1.96e-37: 151: 15.18
+	Mm
		651486 CBL_MOUSE (14-480): 0: 690: 45.28		CSK_MOUSE (403-489): 8.83e-30: 124: 29.89
+	Mm
		834251 CBLB_MOUSE (4-468): 0: 690: 42.48		CSK_MOUSE (403-489): 8.83e-30: 124: 29.89
+	Mm
		651497 CBL_MOUSE (14-480): 0: 690: 45.28		KSYK_MOUSE (409-515): 9.66e-16: 82.8: 22.02
+	Mm
		869540 CBLB_MOUSE (4-468): 0: 690: 42.48		KSYK_MOUSE (409-515): 9.66e-16: 82.8: 22.02
+	Mm
		1189573 CBLB_MOUSE (4-468): 0: 690: 42.48		GRB2_MOUSE (403-491): 8.53e-16: 78.5: 26.97
+	Mm
		651529 CBL_MOUSE (14-480): 0: 690: 45.28		GRB2_MOUSE (403-491): 8.53e-16: 78.5: 26.97
+	Mm
		86322 B9EKI5_MOUSE (4-468): 0: 689: 42.48		GRB2_MOUSE (403-491): 8.53e-16: 78.5: 26.97
+	Rn
		93096 D3ZV15_RAT (14-480): 0: 686: 45.28		GRB2_RAT (403-513): 7.53e-16: 78.9: 25.23