HitPredict

Interactor 1: HOME1 (Q86YM7)
Homer protein homolog 1 (Homer-1)
Gene: HOMER1

Interactor 2: ABI3 (Q9P2A4)
ABI gene family member 3 (New molecule including SH3) (Nesh)
Gene: ABI3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	16189514, 32296183, unassigned1304, unassigned3799
Identification Methods	two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0014069 - postsynaptic density GO:0035591 - signaling adaptor activity GO:0043197 - dendritic spine GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 354 Hs			1 366
+	Hs
		1449321 HOME3_HUMAN (3-354): 3.79e-60: 199: 49.72		ABI3_HUMAN (1-366): 5.41e-88: 271: 100.00
+	Hs
		1449301 HOME2_HUMAN (1-351): 8.61e-56: 187: 51.00		ABI3_HUMAN (1-366): 5.41e-88: 271: 100.00
+	Hs
		1454441 EVL_HUMAN (1-160): 1.26e-28: 116: 21.82		ABI3_HUMAN (1-366): 5.41e-88: 271: 100.00
+	Hs
		896651 VASP_HUMAN (1-146): 3.2e-28: 115: 22.36		ABI3_HUMAN (1-366): 5.41e-88: 271: 100.00
+	Hs
		302210 HOME3_HUMAN (3-354): 3.79e-60: 199: 49.72		NEBL_HUMAN (13-363): 2.11e-35: 139: 14.44
+	Hs
		1449319 HOME3_HUMAN (3-354): 3.79e-60: 199: 49.72		ABI2_HUMAN (109-363): 1.97e-25: 108: 23.18
+	Hs
		1295191 HOME1_HUMAN (1-354): 4.48e-62: 204: 100.00		ABI1_HUMAN (124-363): 6.4e-21: 95.9: 24.49
+	Hs
		1316711 HOME3_HUMAN (3-354): 3.79e-60: 199: 49.72		ABI1_HUMAN (124-363): 6.4e-21: 95.9: 24.49
+	Hs
		302155 VASP_HUMAN (1-146): 3.2e-28: 115: 22.36		NEBL_HUMAN (13-363): 2.11e-35: 139: 14.44
+	Hs
		896644 VASP_HUMAN (1-146): 3.2e-28: 115: 22.36		ABI2_HUMAN (109-363): 1.97e-25: 108: 23.18
+	Hs
		896578 VASP_HUMAN (1-146): 3.2e-28: 115: 22.36		ABI1_HUMAN (124-363): 6.4e-21: 95.9: 24.49
+	Hs
		839737 EPS15_HUMAN (92-321): 5.05e-30: 123: 11.97		GRB2_HUMAN (312-363): 4.05e-14: 72.7: 28.30
+	Hs
		839838 EPS15_HUMAN (92-321): 5.05e-30: 123: 11.97		ITSN2_HUMAN (306-365): 5.4e-13: 72.7: 37.50
+	Hs
		64403 EPS15_HUMAN (92-321): 5.05e-30: 123: 11.97		A6H8W8_HUMAN (306-365): 7.11e-13: 72.3: 37.50
+	Hs
		1280049 EVL_HUMAN (1-160): 1.26e-28: 116: 21.82		SH3R1_HUMAN (254-363): 8.68e-14: 74.7: 20.91
+	Rn
		97303 E9PSY8_RAT (65-332): 5.18e-28: 117: 12.69		ITSN1_RAT (294-363): 6.82e-13: 72.1: 35.14
+	Mm
		839864 EPS15_MOUSE (65-332): 1.06e-27: 116: 13.06		ITSN1_MOUSE (294-363): 7.2e-13: 72.1: 35.14
+	Hs
		896505 VASP_HUMAN (1-146): 3.2e-28: 115: 22.36		GRB2_HUMAN (312-363): 4.05e-14: 72.7: 28.30
+	Hs
		839768 EPS15_HUMAN (92-321): 5.05e-30: 123: 11.97		ITSN1_HUMAN (205-363): 5.28e-10: 63.2: 15.85
+	Cl
		47464 A0A8I3PJA6_CANLF (65-335): 2.14e-29: 121: 11.81		F1PHV6_CANLF (205-363): 4.59e-10: 63.5: 16.46