HitPredict

Interactor 1: HOME3 (Q9NSC5)
Homer protein homolog 3 (Homer-3)
Gene: HOMER3

Interactor 2: ABI3 (Q9P2A4)
ABI gene family member 3 (New molecule including SH3) (Nesh)
Gene: ABI3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.695

Property	Details
Experiments	32296183, 19060904, unassigned1304, unassigned3799
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach, validated two hybrid, two hybrid prey pooling approach, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0014069 - postsynaptic density GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 361 Hs			1 366
+	Hs
		1449301 HOME2_HUMAN (4-357): 6.56e-96: 291: 45.35		ABI3_HUMAN (1-366): 5.41e-88: 271: 100.00
+	Hs
		1295224 HOME1_HUMAN (4-360): 1.4e-87: 269: 50.42		ABI3_HUMAN (1-366): 5.41e-88: 271: 100.00
+	Hs
		302210 HOME3_HUMAN (1-361): 2.62e-97: 294: 100.00		NEBL_HUMAN (13-363): 2.11e-35: 139: 14.44
+	Hs
		1331373 ENAH_HUMAN (4-156): 1.77e-39: 149: 27.39		ABI3_HUMAN (1-366): 5.41e-88: 271: 100.00
+	Hs
		896651 VASP_HUMAN (4-170): 7.21e-35: 133: 23.12		ABI3_HUMAN (1-366): 5.41e-88: 271: 100.00
+	Hs
		1449319 HOME3_HUMAN (1-361): 2.62e-97: 294: 100.00		ABI2_HUMAN (109-363): 1.97e-25: 108: 23.18
+	Hs
		1316711 HOME3_HUMAN (1-361): 2.62e-97: 294: 100.00		ABI1_HUMAN (124-363): 6.4e-21: 95.9: 24.49
+	Hs
		1295191 HOME1_HUMAN (4-360): 1.4e-87: 269: 50.42		ABI1_HUMAN (124-363): 6.4e-21: 95.9: 24.49
+	Hs
		1453438 EP15R_HUMAN (78-354): 2.28e-57: 201: 14.74		ITSN2_HUMAN (306-365): 5.4e-13: 72.7: 37.50
+	Hs
		987997 EP15R_HUMAN (78-354): 2.28e-57: 201: 14.74		GRB2_HUMAN (312-363): 4.05e-14: 72.7: 28.30
+	Hs
		64409 EP15R_HUMAN (78-354): 2.28e-57: 201: 14.74		A6H8W8_HUMAN (306-365): 7.11e-13: 72.3: 37.50
+	Hs
		302155 VASP_HUMAN (4-170): 7.21e-35: 133: 23.12		NEBL_HUMAN (13-363): 2.11e-35: 139: 14.44
+	Hs
		1154186 EP15R_HUMAN (78-354): 2.28e-57: 201: 14.74		ITSN1_HUMAN (205-363): 5.28e-10: 63.2: 15.85
+	Mm
		1221960 EP15R_MOUSE (78-353): 1.03e-52: 189: 14.44		ITSN1_MOUSE (294-363): 7.2e-13: 72.1: 35.14
+	Hs
		1331368 ENAH_HUMAN (4-156): 1.77e-39: 149: 27.39		ABI2_HUMAN (109-363): 1.97e-25: 108: 23.18
+	Hs
		1316675 ENAH_HUMAN (4-156): 1.77e-39: 149: 27.39		ABI1_HUMAN (124-363): 6.4e-21: 95.9: 24.49
+	Hs
		896644 VASP_HUMAN (4-170): 7.21e-35: 133: 23.12		ABI2_HUMAN (109-363): 1.97e-25: 108: 23.18
+	Dm
		1346044 ENA_DROME (2-163): 8e-35: 137: 18.82		Q9Y0S9_DROME (260-364): 6.86e-21: 95.5: 38.32
+	Hs
		896578 VASP_HUMAN (4-170): 7.21e-35: 133: 23.12		ABI1_HUMAN (124-363): 6.4e-21: 95.9: 24.49
+	Hs
		896505 VASP_HUMAN (4-170): 7.21e-35: 133: 23.12		GRB2_HUMAN (312-363): 4.05e-14: 72.7: 28.30