HitPredict

Interactor 1: MYD88 (Q99836)
Myeloid differentiation primary response protein MyD88
Gene: MYD88

Interactor 2: TLR10 (Q9BXR5)
Toll-like receptor 10 (CD antigen CD290)
Gene: TLR10

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15728506
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0045087 - innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 296 Hs			1 811
+	Hs
		1306793 MYD88_HUMAN (14-296): 4.31e-123: 355: 100.00		TLR6_HUMAN (23-790): 1.28e-111: 360: 46.96
+	Hs
		1073330 MYD88_HUMAN (14-296): 4.31e-123: 355: 100.00		TLR1_HUMAN (4-785): 5.21e-111: 358: 46.45
+	Mm
		607582 MYD88_MOUSE (1-296): 6.79e-129: 370: 81.76		TLR2_MOUSE (7-775): 1.83e-99: 328: 28.01
+	Hs
		237513 MYD88_HUMAN (14-296): 4.31e-123: 355: 100.00		TLR2_HUMAN (7-775): 2.55e-101: 333: 27.37
+	Hs
		1073332 TLR10_HUMAN (145-295): 3.61e-51: 181: 19.88		TLR1_HUMAN (4-785): 5.21e-111: 358: 46.45
+	Hs
		237517 TLR10_HUMAN (145-295): 3.61e-51: 181: 19.88		TLR2_HUMAN (7-775): 2.55e-101: 333: 27.37
+	Hs
		1306783 MYD88_HUMAN (14-296): 4.31e-123: 355: 100.00		TLR9_HUMAN (13-578): 1.58e-36: 150: 15.93
+	Mm
		607577 MYD88_MOUSE (1-296): 6.79e-129: 370: 81.76		TLR9_MOUSE (14-522): 7.57e-30: 129: 14.84
+	Dm
		1178824 Q7K105_DROME (18-293): 1.51e-87: 273: 25.48		TOLL6_DROME (1-650): 2.22e-42: 169: 13.82
+	Hs
		237435 MYD88_HUMAN (14-296): 4.31e-123: 355: 100.00		TLR5_HUMAN (3-437): 5.11e-16: 84.6: 13.26
+	Mm
		607581 MYD88_MOUSE (1-296): 6.79e-129: 370: 81.76		TLR4_MOUSE (7-255): 1.36e-10: 67.3: 12.20
+	Hs
		1306788 MYD88_HUMAN (14-296): 4.31e-123: 355: 100.00		TLR7_HUMAN (1-131): 7.74e-13: 74.6: 23.81
+	Hs
		179958 MYD88_HUMAN (14-296): 4.31e-123: 355: 100.00		TLR3_HUMAN (1-300): 1.72e-12: 73.4: 13.84
+	Hs
		120173 MYD88_HUMAN (14-296): 4.31e-123: 355: 100.00		TLR4_HUMAN (5-457): 2.31e-12: 73: 11.82
+	Dm
		445966 TOLL_DROME (142-294): 4.66e-51: 182: 24.38		Q58S70_DROME (447-735): 1.08e-72: 243: 23.73
+	Hs
		1306784 MYD88_HUMAN (14-296): 4.31e-123: 355: 100.00		TLR8_HUMAN (286-599): 2.9e-11: 69.6: 12.62
+	Dm
		1178820 Q7K105_DROME (18-293): 1.51e-87: 273: 25.48		TOLL7_DROME (4-457): 7.81e-35: 145: 14.38
+	Dm
		445967 Q7K105_DROME (18-293): 1.51e-87: 273: 25.48		TOLL_DROME (250-660): 8.84e-15: 80.7: 10.74
+	Dm
		445962 TOLL_DROME (142-294): 4.66e-51: 182: 24.38		TOLL_DROME (250-660): 8.84e-15: 80.7: 10.74
+	Dm
		445971 TOLL_DROME (142-294): 4.66e-51: 182: 24.38		Q9VJX9_DROME (50-434): 5.52e-10: 65.2: 13.28