HitPredict

Interactor 1: PK3CD (O00329)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)
Gene: PIK3CD

Interactor 2: PK3CG (P48736)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K)
Gene: PIK3CG

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.52 1.00 0.724

The method score is based on:

Property Details
Experiments 9113989
Identification Methods pull down, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PI3_PI4_kinase~PI3_PI4_kinase, PI3K_C2~PI3_PI4_kinase, PI3K_rbd~PI3_PI4_kinase, PI3Ka~PI3_PI4_kinase, PI3K_C2~PI3Ka, PI3K_C2~PIK3CG_ABD, PI3K_rbd~PI3K_rbd, PI3K_rbd~PI3Ka, PI3Ka~PI3Ka, PI3Ka~PIK3CG_ABD
Common GO terms GO:0001819 - positive regulation of cytokine production
GO:0002250 - adaptive immune response
GO:0002679 - respiratory burst involved in defense response
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
and 20 others

more...
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 1044
Hs

1 1102
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Last updated: 11Aug2025