HitPredict

Interactor 1: BCL9 (O00512)
B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog)
Gene: BCL9

Interactor 2: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	28794006, 35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0035019 - somatic stem cell population maintenance GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1426 Hs			1 317
+	Hs
		138979 BCL9_HUMAN (1-1426): 4.48e-144: 478: 100.00		SOX9_HUMAN (28-260): 6.26e-37: 139: 27.57
+	Hs
		139026 BCL9_HUMAN (1-1426): 4.48e-144: 478: 100.00		SOX17_HUMAN (7-260): 2.4e-33: 128: 27.80
+	Hs
		138985 BCL9_HUMAN (1-1426): 4.48e-144: 478: 100.00		SOX10_HUMAN (25-272): 2.44e-32: 126: 26.52
+	Hs
		138955 BCL9_HUMAN (1-1426): 4.48e-144: 478: 100.00		SOX15_HUMAN (13-118): 1.79e-31: 119: 66.04
+	Hs
		872487 BCL9L_HUMAN (4-1216): 2.03e-17: 90.9: 9.74		SOX2_HUMAN (1-317): 7.52e-76: 236: 100.00
+	Hs
		872546 KMT2C_HUMAN (143-1069): 6.77e-17: 89.4: 13.40		SOX2_HUMAN (1-317): 7.52e-76: 236: 100.00
+	Hs
		775501 NU214_HUMAN (4-1161): 7.63e-16: 85.9: 8.03		SOX2_HUMAN (1-317): 7.52e-76: 236: 100.00
+	Hs
		872329 NCOA6_HUMAN (488-1426): 4.83e-15: 83.2: 9.31		SOX2_HUMAN (1-317): 7.52e-76: 236: 100.00
+	Hs
		872830 CHD7_HUMAN (439-1029): 9.05e-15: 82.4: 11.30		SOX2_HUMAN (1-317): 7.52e-76: 236: 100.00
+	Hs
		873111 CBP_HUMAN (179-1264): 2.43e-29: 130: 12.05		SOX9_HUMAN (28-260): 6.26e-37: 139: 27.57
+	Hs
		1057470 CBP_HUMAN (179-1264): 2.43e-29: 130: 12.05		SOX4_HUMAN (9-289): 1.16e-32: 127: 26.69
+	Hs
		1368470 CBP_HUMAN (179-1264): 2.43e-29: 130: 12.05		SOX7_HUMAN (23-299): 4e-33: 127: 27.03
+	Hs
		776139 CHD7_HUMAN (439-1029): 9.05e-15: 82.4: 11.30		SOX5_HUMAN (2-127): 7.95e-43: 158: 41.27
+	Hs
		1065251 ANR11_HUMAN (201-1034): 1.17e-21: 105: 11.89		SSRP1_HUMAN (22-202): 4.59e-31: 124: 15.93
+	Hs
		873102 KMT2C_HUMAN (143-1069): 6.77e-17: 89.4: 13.40		SOX9_HUMAN (28-260): 6.26e-37: 139: 27.57
+	Hs
		873087 NCOA6_HUMAN (488-1426): 4.83e-15: 83.2: 9.31		SOX9_HUMAN (28-260): 6.26e-37: 139: 27.57
+	Hs
		1338275 KMT2C_HUMAN (143-1069): 6.77e-17: 89.4: 13.40		SOX17_HUMAN (7-260): 2.4e-33: 128: 27.80
+	Hs
		1338269 KMT2C_HUMAN (143-1069): 6.77e-17: 89.4: 13.40		SOX7_HUMAN (23-299): 4e-33: 127: 27.03
+	Hs
		1130601 NCOA6_HUMAN (488-1426): 4.83e-15: 83.2: 9.31		SOX17_HUMAN (7-260): 2.4e-33: 128: 27.80
+	Hs
		776259 CHD7_HUMAN (439-1029): 9.05e-15: 82.4: 11.30		SOX6_HUMAN (29-246): 1.78e-28: 117: 23.39