HitPredict

Interactor 1: SOCS2 (O14508)
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)
Gene: SOCS2

Interactor 2: FAK2 (Q14289)
Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
Gene: PTK2B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	20543098
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Hs			1 1009
+	Hs
		155943 SOCS3_HUMAN (16-194): 7.3e-48: 157: 27.89		FAK2_HUMAN (1-1009): 0: 1077: 100.00
+	Mm
		813525 FYN_MOUSE (1-172): 9.01e-45: 157: 14.44		Q8C2G0_MOUSE (1-1009): 0: 1000: 91.28
+	Hs
		155105 SOCS2_HUMAN (1-198): 2.97e-62: 193: 100.00		FAK1_HUMAN (39-1000): 0: 840: 44.26
+	Hs
		155933 SOCS3_HUMAN (16-194): 7.3e-48: 157: 27.89		FAK1_HUMAN (39-1000): 0: 840: 44.26
+	Mm
		757443 FYN_MOUSE (1-172): 9.01e-45: 157: 14.44		FAK1_MOUSE (39-1000): 0: 833: 44.26
+	Hs
		116828 SOCS3_HUMAN (16-194): 7.3e-48: 157: 27.89		I6L996_HUMAN (407-1000): 1.1e-177: 535: 45.03
+	Hs
		155888 SOCS3_HUMAN (16-194): 7.3e-48: 157: 27.89		ABL1_HUMAN (264-974): 2.2e-136: 440: 21.99
+	Hs
		362121 FYN_HUMAN (1-172): 1.04e-44: 157: 14.44		ABL1_HUMAN (264-974): 2.2e-136: 440: 21.99
+	Hs
		155112 SOCS2_HUMAN (1-198): 2.97e-62: 193: 100.00		ERBB4_HUMAN (404-884): 8.79e-117: 391: 27.45
+	Hs
		155063 SOCS2_HUMAN (1-198): 2.97e-62: 193: 100.00		LCK_HUMAN (279-694): 1.85e-123: 387: 29.36
+	Hs
		155080 SOCS2_HUMAN (1-198): 2.97e-62: 193: 100.00		EPHA2_HUMAN (362-719): 1.58e-115: 380: 32.04
+	Hs
		155890 SOCS3_HUMAN (16-194): 7.3e-48: 157: 27.89		ERBB2_HUMAN (286-908): 2.14e-123: 408: 21.96
+	Hs
		410520 FYN_HUMAN (1-172): 1.04e-44: 157: 14.44		ERBB2_HUMAN (286-908): 2.14e-123: 408: 21.96
+	Hs
		155065 SOCS2_HUMAN (1-198): 2.97e-62: 193: 100.00		YES_HUMAN (288-695): 1.2e-116: 370: 28.71
+	Hs
		155946 SOCS3_HUMAN (16-194): 7.3e-48: 157: 27.89		ERBB4_HUMAN (404-884): 8.79e-117: 391: 27.45
+	Hs
		155893 SOCS3_HUMAN (16-194): 7.3e-48: 157: 27.89		LCK_HUMAN (279-694): 1.85e-123: 387: 29.36
+	Hs
		155151 SOCS7_HUMAN (31-196): 4.86e-49: 169: 32.18		YES_HUMAN (288-695): 1.2e-116: 370: 28.71
+	Hs
		155896 SOCS3_HUMAN (16-194): 7.3e-48: 157: 27.89		YES_HUMAN (288-695): 1.2e-116: 370: 28.71
+	Hs
		155910 SOCS3_HUMAN (16-194): 7.3e-48: 157: 27.89		FGFR3_HUMAN (351-683): 8.55e-109: 358: 31.39
+	Mm
		813512 FYN_MOUSE (1-172): 9.01e-45: 157: 14.44		EPHA4_MOUSE (425-709): 4.37e-56: 213: 38.19