HitPredict

Interactor 1: NDC80 (O14777)
Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC)
Gene: NDC80

Interactor 2: NDEL1 (Q9GZM8)
Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1)
Gene: NDEL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	25416956, 29892012
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000132 - establishment of mitotic spindle orientation GO:0000776 - kinetochore GO:0005813 - centrosome GO:0005829 - cytosol GO:0007059 - chromosome segregation and 1 others more... GO:0008017 - microtubule binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 642 Hs			1 345
+	Hs
		155149 NDC80_HUMAN (1-642): 1.46e-79: 266: 100.00		EP15R_HUMAN (7-325): 7e-42: 157: 12.81
+	Hs
		155141 NDC80_HUMAN (1-642): 1.46e-79: 266: 100.00		NDE1_HUMAN (3-321): 2.95e-41: 149: 55.25
+	Hs
		111087 NDC80_HUMAN (1-642): 1.46e-79: 266: 100.00		I3L3G9_HUMAN (3-264): 3.72e-32: 123: 60.67
+	Hs
		155163 NDC80_HUMAN (1-642): 1.46e-79: 266: 100.00		ICE1_HUMAN (11-277): 4.04e-22: 99.7: 15.83
+	Hs
		725002 UACA_HUMAN (191-641): 1.51e-30: 130: 13.88		MYH9_HUMAN (2-223): 7.48e-24: 105: 17.57
+	Hs
		256695 RFIP3_HUMAN (192-552): 3.91e-29: 125: 17.25		RFIP3_HUMAN (4-235): 1.56e-22: 100: 14.66
+	Hs
		256707 RFIP3_HUMAN (192-552): 3.91e-29: 125: 17.25		RFIP4_HUMAN (1-235): 5.51e-20: 92.8: 15.75
+	Rn
		222472 MRCKA_RAT (181-627): 1.66e-21: 102: 10.82		MRCKA_RAT (2-209): 6.52e-27: 113: 18.22
+	Rn
		222476 MRCKB_RAT (266-642): 2.4e-19: 95.2: 10.61		MRCKA_RAT (2-209): 6.52e-27: 113: 18.22
+	Hs
		1137917 MRCKB_HUMAN (258-642): 1.73e-21: 102: 12.78		MRCKA_HUMAN (2-204): 1.99e-20: 94.7: 17.41
+	Hs
		148460 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		CTRO_HUMAN (12-211): 2.55e-24: 106: 19.32
+	Hs
		724686 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MYH9_HUMAN (2-223): 7.48e-24: 105: 17.57
+	Hs
		724687 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MYH10_HUMAN (2-228): 6.16e-23: 102: 18.06
+	Hs
		724873 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		CYTSA_HUMAN (2-331): 7.36e-23: 102: 16.06
+	Hs
		148466 MYH11_HUMAN (180-641): 3.92e-16: 84.8: 12.24		CTRO_HUMAN (12-211): 2.55e-24: 106: 19.32
+	Mm
		93570 DESP_MOUSE (190-642): 1.18e-15: 83.5: 15.27		MYH9_MOUSE (2-228): 2.1e-24: 106: 16.30
+	Hs
		148461 MYH10_HUMAN (171-636): 1.34e-15: 83.3: 12.84		CTRO_HUMAN (12-211): 2.55e-24: 106: 19.32
+	Hs
		1137871 MRCKA_HUMAN (140-627): 3.84e-19: 94.5: 11.42		MRCKA_HUMAN (2-204): 1.99e-20: 94.7: 17.41
+	Hs
		725097 MYH11_HUMAN (180-641): 3.92e-16: 84.8: 12.24		MYH10_HUMAN (2-228): 6.16e-23: 102: 18.06
+	Hs
		724895 MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50		MYH14_HUMAN (2-216): 1.78e-13: 73.5: 19.54