HitPredict

Interactor 1: SOCS2 (O14508)
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)
Gene: SOCS2

Interactor 2: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.80	0.595

Property	Details
Experiments	28883622
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Hs			1 976
+	Hs
		462998 YES_HUMAN (1-175): 8.85e-43: 152: 13.12		EPHA2_HUMAN (1-976): 0: 1124: 100.00
+	Hs
		440461 FYN_HUMAN (1-172): 1.04e-44: 157: 14.44		EPHA5_HUMAN (11-976): 0: 1115: 51.34
+	Mm
		813512 FYN_MOUSE (1-172): 9.01e-45: 157: 14.44		EPHA4_MOUSE (1-974): 0: 1113: 50.56
+	Hs
		440462 FYN_HUMAN (1-172): 1.04e-44: 157: 14.44		EPHA4_HUMAN (1-974): 0: 1110: 50.35
+	Hs
		440391 FYN_HUMAN (1-172): 1.04e-44: 157: 14.44		EPHA3_HUMAN (24-976): 0: 1096: 50.98
+	Hs
		462999 YES_HUMAN (1-175): 8.85e-43: 152: 13.12		EPHB2_HUMAN (28-973): 0: 1077: 48.29
+	Hs
		440460 FYN_HUMAN (1-172): 1.04e-44: 157: 14.44		EPHB3_HUMAN (22-972): 0: 1040: 47.33
+	Hs
		440392 FYN_HUMAN (1-172): 1.04e-44: 157: 14.44		EPHA8_HUMAN (28-975): 0: 1037: 46.72
+	Hs
		440362 FYN_HUMAN (1-172): 1.04e-44: 157: 14.44		EPHA1_HUMAN (17-967): 0: 947: 49.28
+	Hs
		155066 SOCS2_HUMAN (1-198): 2.97e-62: 193: 100.00		IGF1R_HUMAN (393-877): 1.45e-133: 437: 29.90
+	Hs
		155150 SOCS7_HUMAN (31-196): 4.86e-49: 169: 32.18		INSR_HUMAN (281-911): 2.91e-136: 444: 24.78
+	Hs
		155914 SOCS3_HUMAN (16-194): 7.3e-48: 157: 27.89		UFO_HUMAN (294-911): 1.96e-144: 454: 24.15
+	Hs
		155892 SOCS3_HUMAN (16-194): 7.3e-48: 157: 27.89		INSR_HUMAN (281-911): 2.91e-136: 444: 24.78
+	Hs
		155897 SOCS3_HUMAN (16-194): 7.3e-48: 157: 27.89		IGF1R_HUMAN (393-877): 1.45e-133: 437: 29.90
+	Mm
		205454 SOCS3_MOUSE (16-194): 3.96e-47: 156: 27.89		INSR_MOUSE (386-873): 6.47e-134: 438: 29.96
+	Hs
		155910 SOCS3_HUMAN (16-194): 7.3e-48: 157: 27.89		FGFR3_HUMAN (381-889): 3.37e-136: 430: 24.65
+	Hs
		440428 FYN_HUMAN (1-172): 1.04e-44: 157: 14.44		FRK_HUMAN (525-864): 4.96e-64: 226: 37.46
+	Hs
		473378 ABL2_HUMAN (3-174): 1.38e-41: 151: 18.86		HCK_HUMAN (591-880): 1.47e-65: 231: 42.12
+	Hs
		462946 YES_HUMAN (1-175): 8.85e-43: 152: 13.12		LYN_HUMAN (607-879): 2.07e-64: 228: 42.91
+	Hs
		463291 FGR_HUMAN (1-172): 1.42e-42: 151: 17.78		LYN_HUMAN (607-879): 2.07e-64: 228: 42.91