HitPredict

Interactor 1: SOCS2 (O14508)
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)
Gene: SOCS2

Interactor 2: CACL1 (Q86Y37)
CDK2-associated and cullin domain-containing protein 1 (Cdk-associated cullin 1)
Gene: CACUL1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.80	0.595

Property	Details
Experiments	28883622
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Hs			1 369
+	Hs
		155108 SOCS2_HUMAN (1-198): 2.97e-62: 193: 100.00		CUL4A_HUMAN (76-353): 3.19e-78: 257: 16.03
+	Hs
		155940 SOCS3_HUMAN (16-194): 7.3e-48: 157: 27.89		CUL4B_HUMAN (59-353): 1.43e-83: 273: 15.18
+	Hs
		362284 ABL1_HUMAN (3-174): 1.28e-40: 148: 19.54		CUL4B_HUMAN (59-353): 1.43e-83: 273: 15.18
+	Hs
		840955 ABL2_HUMAN (3-174): 1.38e-41: 151: 18.86		CUL4A_HUMAN (76-353): 3.19e-78: 257: 16.03
+	Hs
		362283 ABL1_HUMAN (3-174): 1.28e-40: 148: 19.54		CUL4A_HUMAN (76-353): 3.19e-78: 257: 16.03
+	Hs
		440067 LCK_HUMAN (1-172): 2.86e-41: 147: 15.63		CUL3_HUMAN (106-355): 1.94e-74: 247: 18.36
+	Hs
		1114412 CISH_HUMAN (3-198): 5.51e-42: 143: 38.29		CUL3_HUMAN (106-355): 1.94e-74: 247: 18.36
+	Hs
		155125 SOCS2_HUMAN (1-198): 2.97e-62: 193: 100.00		CUL5_HUMAN (133-355): 3.18e-50: 181: 8.44
+	Mm
		205447 SOCS2_MOUSE (1-198): 6.57e-61: 189: 93.94		CUL5_MOUSE (133-355): 2.54e-51: 184: 8.86
+	Mm
		1354086 SOCS7_MOUSE (31-196): 5.76e-49: 169: 32.18		CUL5_MOUSE (133-355): 2.54e-51: 184: 8.86
+	Hs
		155175 SOCS7_HUMAN (31-196): 4.86e-49: 169: 32.18		CUL5_HUMAN (133-355): 3.18e-50: 181: 8.44
+	Mm
		205475 SOCS3_MOUSE (16-194): 3.96e-47: 156: 27.89		CUL5_MOUSE (133-355): 2.54e-51: 184: 8.86
+	Mm
		1223902 CISH_MOUSE (3-198): 3.29e-46: 154: 37.10		CUL5_MOUSE (133-355): 2.54e-51: 184: 8.86
+	Hs
		155960 SOCS3_HUMAN (16-194): 7.3e-48: 157: 27.89		CUL5_HUMAN (133-355): 3.18e-50: 181: 8.44
+	Hs
		1112999 CISH_HUMAN (3-198): 5.51e-42: 143: 38.29		CUL2_HUMAN (123-353): 5.52e-54: 191: 9.41
+	Hs
		1360860 SOCS4_HUMAN (19-197): 1.89e-40: 144: 28.73		CUL5_HUMAN (133-355): 3.18e-50: 181: 8.44
+	Mm
		1362447 SOCS4_MOUSE (9-197): 3.08e-39: 140: 27.23		CUL5_MOUSE (133-355): 2.54e-51: 184: 8.86
+	Hs
		1371879 CISH_HUMAN (3-198): 5.51e-42: 143: 38.29		CUL5_HUMAN (133-355): 3.18e-50: 181: 8.44
+	Mm
		1424095 SOCS6_MOUSE (35-196): 1.12e-38: 140: 33.73		CUL5_MOUSE (133-355): 2.54e-51: 184: 8.86
+	Hs
		156064 SOCS6_HUMAN (35-196): 3.8e-39: 142: 33.73		CUL5_HUMAN (133-355): 3.18e-50: 181: 8.44