HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.689

Property	Details
Experiments	24438103, 30166453, 17135358, 15601820
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 780
+	Hs
		1360860 SOCS4_HUMAN (16-221): 1.21e-53: 179: 20.29		CUL5_HUMAN (1-780): 0: 791: 100.00
+	Hs
		155175 SOCS7_HUMAN (13-221): 6.01e-51: 175: 24.17		CUL5_HUMAN (1-780): 0: 791: 100.00
+	Mm
		1362447 SOCS4_MOUSE (16-221): 3.5e-53: 178: 20.77		CUL5_MOUSE (1-780): 0: 785: 98.46
+	Mm
		205475 SOCS3_MOUSE (1-225): 1.02e-54: 176: 96.89		CUL5_MOUSE (1-780): 0: 785: 98.46
+	Mm
		1354086 SOCS7_MOUSE (13-221): 4.59e-51: 175: 24.17		CUL5_MOUSE (1-780): 0: 785: 98.46
+	Hs
		273313 SOCS5_HUMAN (23-221): 1.49e-47: 165: 21.00		CUL5_HUMAN (1-780): 0: 791: 100.00
+	Mm
		1424095 SOCS6_MOUSE (34-220): 9.79e-49: 168: 26.32		CUL5_MOUSE (1-780): 0: 785: 98.46
+	Mm
		236703 SOCS5_MOUSE (23-221): 4.68e-47: 164: 21.00		CUL5_MOUSE (1-780): 0: 785: 98.46
+	Hs
		1371879 CISH_HUMAN (13-221): 3.21e-46: 155: 30.62		CUL5_HUMAN (1-780): 0: 791: 100.00
+	Hs
		155125 SOCS2_HUMAN (3-221): 1.43e-46: 154: 28.31		CUL5_HUMAN (1-780): 0: 791: 100.00
+	Mm
		1223902 CISH_MOUSE (13-221): 2.37e-47: 158: 29.86		CUL5_MOUSE (1-780): 0: 785: 98.46
+	Mm
		205447 SOCS2_MOUSE (3-221): 3.21e-46: 153: 28.31		CUL5_MOUSE (1-780): 0: 785: 98.46
+	Hs
		156064 SOCS6_HUMAN (15-220): 6.8e-40: 145: 22.64		CUL5_HUMAN (1-780): 0: 791: 100.00
+	Hs
		155940 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		CUL4B_HUMAN (16-780): 0: 735: 25.39
+	Hs
		1114412 CISH_HUMAN (13-221): 3.21e-46: 155: 30.62		CUL3_HUMAN (8-780): 0: 753: 22.96
+	Hs
		440067 LCK_HUMAN (34-219): 1.82e-43: 154: 15.77		CUL3_HUMAN (8-780): 0: 753: 22.96
+	Hs
		1114624 VAV3_HUMAN (24-202): 1.17e-41: 152: 14.53		CUL3_HUMAN (8-780): 0: 753: 22.96
+	Hs
		155108 SOCS2_HUMAN (3-221): 1.43e-46: 154: 28.31		CUL4A_HUMAN (16-780): 0: 743: 24.48
+	Hs
		1112999 CISH_HUMAN (13-221): 3.21e-46: 155: 30.62		CUL2_HUMAN (6-780): 0: 697: 26.36
+	Dm
		198228 O18683_DROME (18-158): 2.67e-38: 140: 17.02		CUL1_DROME (3-780): 0: 691: 25.99